Universität zu Köln

Amft, Maren, Bzdok, Danilo, Laird, Angela R., Fox, Peter T., Schilbach, Leonhard ORCID: 0000-0001-5547-8309 and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2015). Definition and characterization of an extended social-affective default network. Brain Struct. Funct., 220 (2). S. 1031 - 1050. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1863-2661

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Abstract

Recent evidence suggests considerable overlap between the default mode network (DMN) and regions involved in social, affective and introspective processes. We considered these overlapping regions as the social-affective part of the DMN. In this study, we established a robust mapping of the underlying brain network formed by these regions and those strongly connected to them (the extended social-affective default network). We first seeded meta-analytic connectivity modeling and resting-state analyses in the meta-analytically defined DMN regions that showed statistical overlap with regions associated with social and affective processing. Consensus connectivity of each seed was subsequently delineated by a conjunction across both connectivity analyses. We then functionally characterized the ensuing regions and performed several cluster analyses. Among the identified regions, the amygdala/hippocampus formed a cluster associated with emotional processes and memory functions. The ventral striatum, anterior cingulum, subgenual cingulum and ventromedial prefrontal cortex formed a heterogeneous subgroup associated with motivation, reward and cognitive modulation of affect. Posterior cingulum/precuneus and dorsomedial prefrontal cortex were associated with mentalizing, self-reference and autobiographic information. The cluster formed by the temporo-parietal junction and anterior middle temporal sulcus/gyrus was associated with language and social cognition. Taken together, the current work highlights a robustly interconnected network that may be central to introspective, socio-affective, that is, self- and other-related mental processes.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Amft, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Bzdok, Danilo UNSPECIFIED UNSPECIFIED UNSPECIFIED Laird, Angela R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fox, Peter T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-406702
DOI:	10.1007/s00429-013-0698-0
Journal or Publication Title:	Brain Struct. Funct.
Volume:	220
Number:	2
Page Range:	S. 1031 - 1050
Date:	2015
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1863-2661
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TEMPORO-PARIETAL JUNCTION; MEDIAL PREFRONTAL CORTEX; LIKELIHOOD ESTIMATION METAANALYSIS; RIGHT TEMPOROPARIETAL JUNCTION; STATE FUNCTIONAL CONNECTIVITY; ANTERIOR CINGULATE CORTEX; MODE NETWORK; BRAIN-FUNCTION; ALZHEIMERS-DISEASE; SELF-REFLECTION Multiple languages Anatomy & Morphology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40670