Universität zu Köln

Zeschel, Eike, Bingmann, Tiffany, Bechdolf, Andreas, Krueger-Oezguerdal, Seza, Correll, Christoph U., Leopold, Karolina, Pfennig, Andrea, Bauer, Michael and Juckel, Georg (2015). Temperament and prodromal symptoms prior to first manic/hypomanic episodes: Results from a pilot study. J. Affect. Disord., 173. S. 39 - 45. AMSTERDAM: ELSEVIER. ISSN 1573-2517

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Abstract

Background: Prodromal symptoms prior to first episode mania/hypomania have been reported. However, the relationship between temperament and manic/hypomanic prodromal symptoms has not been investigated. We hypothesized that subjects scoring higher on cyclothymic and irritable temperament scales show more manic/hypomanic prodromal symptoms. Method: Euthymic patients diagnosed with bipolar-I or -ll disorder within 8 years underwent retrospective assessments with the Temperament Evaluation of Memphis, Pisa, Paris and San Diegoautoquestionnaire (TEMPS-A) and the Bipolar Prod rome Symptom Scale-Retrospective (BPSS-R). Results: Among 39 subjects (36.1 +/- 9.9 years, females=59%, bipolar-I-62%) 100% and 92.3% reported subthreshold mania (mean-7.4 +/- 2.9) or subthreshold depressive symptoms (mean-2 +/- 1.5), and 87.2% and 43.6% reported general psychopathology (mean-3.2 +/- 2.0) or subthreshold psychotic symptoms (mean-0.7 +/- 1.0) prior to their first hypo-/manic episode. Subjects with higher cyclothymic and irritable temperament scores showed more subthreshold symptoms prior to the first manic/ hypomanic episode, mainly subthreshold hypo-/manic symptoms (cyclothymic temperament r=0.430; p=0.006; irritable temperament r=0.330; p =0.040), general psychopathology symptoms (cyclothymic temperament r=0.316; p=0.05; irritable temperament r=0.349; p=0.029) and subthreshold psychotic symptoms (cyclothymic temperament r=0.413; p=0.009). In regression analyses, cyclothymic temperament explained 16.1% and 12.5% of the variance of the BPSS-R total score (p=0.045) and psychosis subscore (p =0.029). Limitations: Retrospective study, no control group, small sample size. Conclusion: We present data, which indicate a relationship between cyclothymic and irritable temperament and proclromal symptoms prior to the first manic/hypomanic episode. These findings support the notion that assessing cyclothymic temperament to identify people at-risk of developing bipolar-I and -ll disorder may help to increase the predictive validity of applied at-risk criteria. (C) 2014 Elsevier B.V. All rights reserved

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zeschel, Eike UNSPECIFIED UNSPECIFIED UNSPECIFIED Bingmann, Tiffany UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger-Oezguerdal, Seza UNSPECIFIED UNSPECIFIED UNSPECIFIED Correll, Christoph U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Leopold, Karolina UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfennig, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Juckel, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-407209
DOI:	10.1016/j.jad.2014.10.031
Journal or Publication Title:	J. Affect. Disord.
Volume:	173
Page Range:	S. 39 - 45
Date:	2015
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1573-2517
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HELP-SEEKING ADOLESCENTS; BIPOLAR DISORDER; TEMPS-A; NEUROCOGNITIVE FEATURES; EARLY INTERVENTION; RATING-SCALE; RISK; MOOD; SCHIZOPHRENIA; MANIA Multiple languages Clinical Neurology; Psychiatry Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/40720