Kreuter, Alexander, van Eijk, Tina, Lehmann, Percy, Fischer, Matthias, Horn, Thomas, Assaf, Chalid, Schley, Gaston, Herbst, Rudolf, Kellner, Ivonne, Weisbrich, Christiane, Hyun, Julia, Wieland, Ulrike, Schlaak, Max, Ruebben, Albert and Lommel, Kerstin (2015). Electrochemotherapy in advanced skin tumors and cutaneous metastases - a retrospective multicenter analysis. J. Dtsch. Dermatol. Ges., 13 (4). S. 308 - 317. HOBOKEN: WILEY. ISSN 1610-0387
Full text not available from this repository.Abstract
Background and objectives: Following classic treatments such as chemotherapy or radiation, only few therapeutic options remain for widespread skin tumors or cutaneous metastases. In such cases, electrochemotherapy can be considered as an alternative therapy. Patients and methods: In this retrospective study, clinical features, treatment-response, and side effects were evaluated in 56 patients treated with electrochemotherapy at 6 German dermatology departments. Results: Mean age of the patient cohort (14 men, 42 women) was 69.3 years. Overall, 20 patients with skin metastasis of advanced malignant melanoma, 13 patients with metastasized breast cancer, 15 patients with primary squamous cell carcinoma of the skin or metastases of carcinoma of different origin, and 8 patients with cutaneous lymphoma or sarcoma were included. Overall response rate was 44.6 % (10.7 % complete response; 33.9 % partial response). In contrast, 31 (55.4 %) patients did not respond (12.5 %, stable disease; 42.9 % tumor progression). Melanomas and cutaneous lymphomas or sarcomas had a significantly better response than carcinomas. In about a quarter of patients, improvement of tumor-induced exudation, foetor, and chronic bleeding was observed. Conclusions: Electrochemotherapy was effective in about half of the patients with advanced tumors, with few side-effects. Response to treatment seems to depend on the tumor entity.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Creators: |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| URN: | urn:nbn:de:hbz:38-408293 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1111/ddg.12583 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | J. Dtsch. Dermatol. Ges. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Volume: | 13 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number: | 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Page Range: | S. 308 - 317 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Date: | 2015 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Publisher: | WILEY | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Place of Publication: | HOBOKEN | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1610-0387 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Language: | German | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Uncontrolled Keywords: |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/40829 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
 |
View Item |