Universität zu Köln

Palma, Luis Mario Aguirre, Gehrke, Iris and Kreuzer, Karl-Anton (2015). Angiogenic factors in chronic lymphocytic leukaemia (CLL): Where do we stand? Crit. Rev. Oncol./Hematol., 93 (3). S. 225 - 237. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-0461

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Abstract

The role of angiogenesis in haematological malignancies such as chronic lymphocytic leukaemia (CLL) is difficult to envision, because leukaemia cells are not dependent on a network of blood vessels to support basic physiological requirements. Regardless, CLL cells secrete high levels of major angiogenic factors, such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and platelet derived growth factor (PDGF). Nonetheless, it remains unclear how most angiogenic factors regulate accumulation and delayed apoptosis of CLL cells. Angiogenic factors such as leptin, granulocyte colony-stimulating factor (G-CSF), follistatin, angiopoietin-1 (Ang1), angiogenin (ANG), midkine (MK), pleiotrophin (PTN), progranulin (PGRN), proliferin (PLF), placental growth factor (PIGF), and endothelial locus-1 (Del-1), represent novel therapeutic targets of future CLL research but have remained widely overlooked. This review aims to outline our current understanding of angiogenic growth factors and their relationship with CLL, a still uncured haematopoietic malignancy. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Palma, Luis Mario Aguirre UNSPECIFIED UNSPECIFIED UNSPECIFIED Gehrke, Iris UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreuzer, Karl-Anton UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-411007
DOI:	10.1016/j.critrevonc.2014.10.007
Journal or Publication Title:	Crit. Rev. Oncol./Hematol.
Volume:	93
Number:	3
Page Range:	S. 225 - 237
Date:	2015
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-0461
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COLONY-STIMULATING FACTOR; GROWTH-FACTOR PROGRANULIN; DEVELOPMENTAL ENDOTHELIAL LOCUS-1; RECEPTOR TYROSINE KINASE; FOLLISTATIN-RELATED GENE; TUMOR-GROWTH; ACTIVIN-A; PROGNOSTIC-FACTOR; BINDING-PROTEIN; CANCER-THERAPY Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41100