Universität zu Köln

Proels, Felicitas, Wiegreffe, Christoph and Scaal, Martin (2015). Communication between distant epithelial cells by filopodia-like protrusions during embryonic development. Development, 142 (4). S. 665 - 672. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9129

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Abstract

Long-range intercellular communication is essential for the regulation of embryonic development. Apart from simple diffusion, various modes of signal transfer have been described in the literature. Here, we describe a novel type of cellular extensions found in epithelial cells of the somites in chicken embryos. These filopodia-like protrusions span the subectodermal space overlying the dorsal surface of the somites and contact the ectoderm. We show that these protrusions are actin-and tubulin-positive and require Rac1 for their formation. The presence of glycophosphatidylinositol-anchored proteins and net retrograde trafficking of the transmembrane Wnt-receptor Frizzled-7 along the protrusions indicate their role in signal transport and distribution. Taken together, our data suggest a role of filopodia-like protrusions in mediating signaling events between distant epithelial cells during embryonic development.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Proels, Felicitas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiegreffe, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Scaal, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-412417
DOI:	10.1242/dev.115964
Journal or Publication Title:	Development
Volume:	142
Number:	4
Page Range:	S. 665 - 672
Date:	2015
Publisher:	COMPANY OF BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9129
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GPI-ANCHORED PROTEINS; SURFACE ECTODERM; SOMITES; ORGANIZATION; CHICK; MECHANISM; HOMOLOG; RAC Multiple languages Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41241