Kutsch, Nadine, Hallek, Michael and Eichhorst, Barbara (2015). Emerging therapies for refractory chronic lymphocytic leukemia. Leuk. Lymphoma, 56 (2). S. 285 - 293. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

Chronic lymphocytic leukemia (CLL) that becomes refractory to chemotherapy is associated with a poor outcome. For these patients, some of the novel substances that are currently in clinical development for CLL seem to off er new hope. These agents include small molecules, new antibodies, immunomodulators, kinase inhibitors, BCL-2 antagonists and chimeric antigen receptor transduced T-cells (CARTs) and combine high effi cacy with a good safety profi le. To date, allogeneic stem cell transplant remains the only curative treatment option for patients with relapsed, refractory CLL. However, it is possible that new substances will replace allogeneic stem cell transplant in the near future. This review provides an overview of the currently available data and an outlook on future therapies for chemotherapy refractory CLL.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kutsch, NadineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hallek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichhorst, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-413283
DOI: 10.3109/10428194.2014.917641
Journal or Publication Title: Leuk. Lymphoma
Volume: 56
Number: 2
Page Range: S. 285 - 293
Date: 2015
Publisher: TAYLOR & FRANCIS LTD
Place of Publication: ABINGDON
ISSN: 1029-2403
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PHASE-II TRIAL; HIGH-DOSE METHYLPREDNISOLONE; STEM-CELL TRANSPLANTATION; CD38 EXPRESSION; TP53 MUTATION; OPEN-LABEL; FLUDARABINE; RITUXIMAB; SURVIVAL; CLLMultiple languages
Oncology; HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41328

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