Kutsch, Nadine, Hallek, Michael and Eichhorst, Barbara (2015). Emerging therapies for refractory chronic lymphocytic leukemia. Leuk. Lymphoma, 56 (2). S. 285 - 293. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403
Full text not available from this repository.Abstract
Chronic lymphocytic leukemia (CLL) that becomes refractory to chemotherapy is associated with a poor outcome. For these patients, some of the novel substances that are currently in clinical development for CLL seem to off er new hope. These agents include small molecules, new antibodies, immunomodulators, kinase inhibitors, BCL-2 antagonists and chimeric antigen receptor transduced T-cells (CARTs) and combine high effi cacy with a good safety profi le. To date, allogeneic stem cell transplant remains the only curative treatment option for patients with relapsed, refractory CLL. However, it is possible that new substances will replace allogeneic stem cell transplant in the near future. This review provides an overview of the currently available data and an outlook on future therapies for chemotherapy refractory CLL.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-413283 | ||||||||||||||||
DOI: | 10.3109/10428194.2014.917641 | ||||||||||||||||
Journal or Publication Title: | Leuk. Lymphoma | ||||||||||||||||
Volume: | 56 | ||||||||||||||||
Number: | 2 | ||||||||||||||||
Page Range: | S. 285 - 293 | ||||||||||||||||
Date: | 2015 | ||||||||||||||||
Publisher: | TAYLOR & FRANCIS LTD | ||||||||||||||||
Place of Publication: | ABINGDON | ||||||||||||||||
ISSN: | 1029-2403 | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/41328 |
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