Universität zu Köln

Straka, Christian, Salwender, Hans ORCID: 0000-0001-7803-0814, Schnabel, Brigitte, Sandherr, Michael, Wandt, Hannes, Huebel, Kai, Scheid, Christof, Metzner, Bernd, Hentrich, Marcus, Franke, Daniel, Weidenegger, Gloria, Freund, Mathias, Sezer, Orhan, Einsele, Hermann, Hinke, Axel and Emmerich, Bertold (2015). Granulocyte-colony stimulating factor response is superior to neutropenia duration in predicting the risk of infection after high-dose chemotherapy for myeloma and lymphoma. Leuk. Lymphoma, 56 (2). S. 368 - 377. LONDON: INFORMA HEALTHCARE. ISSN 1029-2403

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Abstract

The patient granulocyte-colony stimulating factor (G-CSF) response is represented by the leukocyte peak in the blood induced by a single dose of G-CSF after chemotherapy, and is correlated with subsequent neutropenic infection risk. General patterns for a meaningful risk group stratification, have not yet been determined. Two independent data sets including a total of 306 cases with myeloma or lymphoma and autologous blood stem cell transplant were available. An infection susceptibility curve plotted according to ranked G-CSF responses from a multicenter study reproduced and validated a curve from the previous single center. Two trend changes were seen within these curves at around 11 000 and 22 000 leukocytes/mu L, which separated three groups with a high, medium and low risk of infection. While G-CSF response is related to the consecutive duration of neutropenia, it retains additional independent predictive information for infection risk (p < 0.0001) and, more important, is a tool available before the onset of the critical period.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Straka, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Salwender, Hans UNSPECIFIED orcid.org/0000-0001-7803-0814 UNSPECIFIED Schnabel, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Sandherr, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Wandt, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Huebel, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzner, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Hentrich, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Franke, Daniel UNSPECIFIED UNSPECIFIED UNSPECIFIED Weidenegger, Gloria UNSPECIFIED UNSPECIFIED UNSPECIFIED Freund, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Sezer, Orhan UNSPECIFIED UNSPECIFIED UNSPECIFIED Einsele, Hermann UNSPECIFIED UNSPECIFIED UNSPECIFIED Hinke, Axel UNSPECIFIED UNSPECIFIED UNSPECIFIED Emmerich, Bertold UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-413305
DOI:	10.3109/10428194.2014.919631
Journal or Publication Title:	Leuk. Lymphoma
Volume:	56
Number:	2
Page Range:	S. 368 - 377
Date:	2015
Publisher:	INFORMA HEALTHCARE
Place of Publication:	LONDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; CLINICAL-PRACTICE GUIDELINE; DIAGNOSED MULTIPLE-MYELOMA; AUTOLOGOUS TRANSPLANTATION; INDUCTION THERAPY; RANDOMIZED-TRIAL; GROWTH-FACTORS; 2010 UPDATE; LENALIDOMIDE Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41330