Ringe, J. D. and Windler, E. (2015). Calcium and vitamin D substitution for osteoporosis. Benefit or risk. Gynakol. Endokrinol., 13 (1). S. 11 - 16. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1610-2908
Full text not available from this repository.Abstract
Insufficient calcium intake results in increased bone resorption leading to osteoporosis. In this situation a normal serum calcium level is maintained at the cost of the skeleton, i.e. development of secondary hyperparathyroidism. Vitamin D enhances intestinal calcium absorption and osteoid mineralization and reduces parathyroid hormone secretion. Therefore, calcium and vitamin D supplements are generally recommended for prevention and as a basic therapy of osteoporosis. When dosing these supplements nutritional calcium and vitamin D synthesis during sun exposure have to be taken into consideration. It is also important to take into consideration that calcium intake and intestinal absorption as well as vitamin D production decrease with increasing age. Calcium intake should be in the range of 1000-1500 mg and vitamin D 800-2000 IU per day or 25-hydroxy-vitamin D plasma levels between 30 and 50 ng/ml. With these dosages hypercalcemia and hypercalciuria are extremely rare adverse events and the risk of kidney stones is very low. Communications of increased cardiovascular events related to long-term calcium or calcium and vitamin D intake induced a significant reduction of prescriptions of corresponding preparations. Other publications, however, communicated cardioprotective effects of vitamin D and recent publications could not confirm an increased risk of cardiovascular events with calcium alone or in combination with vitamin D and even demonstrated reduced mortality. Until final clarification of these discrepant study results a regular moderate intake of calcium and vitamin D supplements within the abovementioned dosage range is recommended.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-413967 | ||||||||||||
DOI: | 10.1007/s10304-014-0644-0 | ||||||||||||
Journal or Publication Title: | Gynakol. Endokrinol. | ||||||||||||
Volume: | 13 | ||||||||||||
Number: | 1 | ||||||||||||
Page Range: | S. 11 - 16 | ||||||||||||
Date: | 2015 | ||||||||||||
Publisher: | SPRINGER HEIDELBERG | ||||||||||||
Place of Publication: | HEIDELBERG | ||||||||||||
ISSN: | 1610-2908 | ||||||||||||
Language: | German | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/41396 |
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