Universität zu Köln

Broeckelmann, Paul J. (2015). Consolidated aspects in the treatment of hodgkin lymphoma. Drug. Cell Ther. Hematol., 3 (3). S. 130 - 144. PAVIA: PAGEPRESS PUBL. ISSN 2281-4884

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Abstract

Accounting for 15% of all lymphomas, Hodgkin lymphoma (HL) is a relatively rare disease but the most common malignancies among young adults. Over the last decades prognosis markedly improved with the refinement of evidence based therapies. Current risk-adapted therapies usually consist of polychemotherapies such as ABVD or BEACOPPesc and up to 90% of all patients may be considered cured after adequate first-line treatment. Due to this favorable development recent research focused on reduction of therapeutic intensity and more individualized approaches. Prognosis is worse in relapsed or refractory HL (rrHL), where high-dose chemotherapy (HDCT) and autologous stem cell transplantation (ASCT) is associated with progression-free survival (PFS) of only 50%. Outcomes tend to be inferior in elderly patients or those ineligible for intensified therapies due to comorbidities. This review delineates the development of current standard approaches in firstline and rrHL treatment and summarizes key findings of recent large scale clinical trials. Innovative approaches including response-guided therapy or implementation of novel agents are covered in a separate article.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Broeckelmann, Paul J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-414955
Journal or Publication Title:	Drug. Cell Ther. Hematol.
Volume:	3
Number:	3
Page Range:	S. 130 - 144
Date:	2015
Publisher:	PAGEPRESS PUBL
Place of Publication:	PAVIA
ISSN:	2281-4884
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; INVOLVED-FIELD RADIOTHERAPY; HIGH-DOSE CHEMOTHERAPY; POSITRON-EMISSION-TOMOGRAPHY; COMBINED-MODALITY TREATMENT; NON-CROSS-RESISTANT; STANFORD-V; COMPREHENSIVE ANALYSIS; INITIAL TREATMENT; RANDOMIZED-TRIAL Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41495