Universität zu Köln

Doulgere, Julia, Otto, Benjamin, Nassour, Maher, Wolters-Eisfeld, Gerrit ORCID: 0000-0002-2984-6515, Rohde, Holger ORCID: 0000-0001-8587-4433, Magnus, Tim, Wagener, Christoph and Streichert, Thomas (2015). Soluble plasma VE-cadherin concentrations are elevated in patients with STEC infection and haemolytic uraemic syndrome: a case-control study. BMJ Open, 5 (3). LONDON: BMJ PUBLISHING GROUP. ISSN 2044-6055

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Abstract

Objectives: To investigate whether the adherens junction protein vascular endothelial cadherin (VE-cadherin) is released during Shiga toxin 2 producing Escherichia coli (STEC) infection with haemolytic uraemic syndrome (HUS) and thus could be used to assist diagnosis. Design: Using data from the large 2011 STEC outbreak in northern Europe, we determined VE-cadherin plasma concentrations in 356 patients distributed over three patient cohorts: patients with STEC infection accompanied by HUS (STEC-HUS), STEC patients without HUS (STEC) and control patients with diarrhoea but without STEC infection. We then looked for associations between VE-cadherin concentrations and disease severity defined by changes in lactate dehydrogenase, haemoglobin, creatinine, platelet count, haptoglobin and neurological symptoms. Setting: This study was conducted at the University Medical Center Hamburg-Eppendorf, Germany. Participants: 79 STEC-HUS patients, 77 STEC patients and 200 control patients were enrolled in the study. Results: We analysed 864 specimens (207 STEC, 449 STEC-HUS and 208 controls) in total. At admission, VE-cadherin concentration tended to be lower in STEC-HUS patients compared to other patients. However, HUS patients later showed an increase in VE-cadherin concentrations with prolonged elevation beyond remission. This pattern clearly differs from that observed in non-HUS patients. Conclusions: VE-cadherin concentrations are elevated in STEC-HUS patients and might be a biomarker reflecting endothelial damage in patients with HUS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Doulgere, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Otto, Benjamin UNSPECIFIED UNSPECIFIED UNSPECIFIED Nassour, Maher UNSPECIFIED UNSPECIFIED UNSPECIFIED Wolters-Eisfeld, Gerrit UNSPECIFIED orcid.org/0000-0002-2984-6515 UNSPECIFIED Rohde, Holger UNSPECIFIED orcid.org/0000-0001-8587-4433 UNSPECIFIED Magnus, Tim UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagener, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-415690
DOI:	10.1136/bmjopen-2014-005659
Journal or Publication Title:	BMJ Open
Volume:	5
Number:	3
Date:	2015
Publisher:	BMJ PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2044-6055
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VASCULAR ENDOTHELIAL-CADHERIN; ESCHERICHIA-COLI INFECTIONS; CELLS; SEPSIS; PERMEABILITY Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41569