Universität zu Köln

Roessler, Jessica, Ammerpohl, Ole, Gutwein, Jana, Steinemann, Doris, Schlegelberger, Brigitte, Weyer, Veronika, Sariyar, Murat, Geffers, Robert, Arnold, Norbert ORCID: 0000-0003-4523-8808, Schmutzler, Rita, Bartram, Claus R., Heinrich, Tilman, Abbas, Mahmoud, Antonopoulos, Wiebke, Schipper, Elisa, Hasemeier, Britta, Kreipe, Hans and Lehmann, Ulrich (2015). The CpG island methylator phenotype in breast cancer is associated with the lobular subtype. Epigenomics, 7 (2). S. 187 - 200. LONDON: FUTURE MEDICINE LTD. ISSN 1750-192X

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Abstract

Background: Aberrations in DNA methylation patterns are well-described in human malignancies. However, the existence of the 'CpG island methylator phenotype' (CIMP) in human breast cancer is still controversial. Materials & methods: Illumina's HumanMethylation 450K BeadChip was used to analyze genome-wide DNA methylation patterns. Chromosomal abnormalities were determined by array-based CGH. Results: Invasive lobular breast carcinomas exhibit the highest number of differentially methylated CpG sites and a strong inverse correlation of aberrant DNA hypermethylation and copy number alterations. Nine differentially methylated regions within seven genes discriminating the investigated subgroups were identified and validated in an independent validation cohort and correlated to a better relapse-free survival. Conclusion: These results depict a clear difference between genetically and epigenetically unstable breast carcinomas indicating different ways of tumor progression and/or initiation, which strongly supports the association of CIMP with the lobular subtype and provide new options for detection and therapy.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roessler, Jessica UNSPECIFIED UNSPECIFIED UNSPECIFIED Ammerpohl, Ole UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutwein, Jana UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinemann, Doris UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlegelberger, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyer, Veronika UNSPECIFIED UNSPECIFIED UNSPECIFIED Sariyar, Murat UNSPECIFIED UNSPECIFIED UNSPECIFIED Geffers, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Arnold, Norbert UNSPECIFIED orcid.org/0000-0003-4523-8808 UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED Bartram, Claus R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinrich, Tilman UNSPECIFIED UNSPECIFIED UNSPECIFIED Abbas, Mahmoud UNSPECIFIED UNSPECIFIED UNSPECIFIED Antonopoulos, Wiebke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schipper, Elisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Hasemeier, Britta UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreipe, Hans UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416697
DOI:	10.2217/EPI.14.74
Journal or Publication Title:	Epigenomics
Volume:	7
Number:	2
Page Range:	S. 187 - 200
Date:	2015
Publisher:	FUTURE MEDICINE LTD
Place of Publication:	LONDON
ISSN:	1750-192X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DNA METHYLATION; EPIGENETIC INACTIVATION; IDH2 MUTATIONS; CELL-LINE; IN-SITU; CARCINOMA; GENES; HYPERMETHYLATION; ARRAY; EXPRESSION Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41669