Universität zu Köln

Hu, Xiaochen, Meiberth, Dix, Newport, Beate and Jessen, Frank (2015). Anatomical Correlates of the Neuropsychiatric Symptoms in Alzheimer's Disease. Curr. Alzheimer Res., 12 (3). S. 266 - 278. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1875-5828

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Abstract

The current study aimed to assess the relationship between the neuropsychiatric symptoms in Alzheimer's disease (AD) and the regional grey matter (GM) volume using voxel based morphometry (VBM). Data of 85 AD patients, 208 subjects with mild cognitive impairment (MCI), and 131 healthy controls were selected from the Alzheimer's Disease Neuroimaging Initiative. Individual VBM models across the entire sample for each items of the Neuropsychiatric Inventory Questionnaire as variables of interest were specified with four nuisance covariates, including age, sex, total intracranial volume (TIV), and Mini-Mental State Examination (MMSE) score. Agitation was related to the GM atrophy in the left inferior frontal/insula and bilateral retrosplenial cortices. Aberrant motor behavior (AMB) was related to the GM reductions in the right basal ganglia. The VBM models were recalculated by specifying three nuisance covariates (age, sex, TIV), and by excluding voxels related to AD severity by applying a MMSE mask. This procedure confirmed the first results, and additionally revealed associations between depression and GM atrophy in the left middle frontal cortex, between agitation and the GM atrophy in the left middle frontal cortex, and between AMB and GM reduction in the right inferior frontal cortex. Hierarchical multiple regression analyses using extracted mean GM value in these additional regions confirmed these associations. Finally, VBM analyses within a subgroup (85 AD patients and 41 MCI converters) largely confirmed the results. Our results suggest that specific patterns of GM atrophy within AD related neurodegeneration predispose to certain neuropsychiatric symptoms, suggesting distinct neurobiological mechanisms.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hu, Xiaochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Meiberth, Dix UNSPECIFIED UNSPECIFIED UNSPECIFIED Newport, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416722
DOI:	10.2174/1567205012666150302154914
Journal or Publication Title:	Curr. Alzheimer Res.
Volume:	12
Number:	3
Page Range:	S. 266 - 278
Date:	2015
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	1875-5828
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; VOXEL-BASED MORPHOMETRY; CEREBRAL-BLOOD-FLOW; DEPRESSIVE SYMPTOMS; DEMENTIA; APATHY; HYPOPERFUSION; LOBE; METABOLISM; AGITATION Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41672