Universität zu Köln

Vahlensieck, Winfried, Theurer, Christoph, Pfitzer, Edith, Patz, Brigitte, Banik, Norbert and Engelmann, Udo (2015). Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study. Urol.Int., 94 (3). S. 286 - 296. BASEL: KARGER. ISSN 1423-0399

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Abstract

Introduction: The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). Subjects and Methods: A total of 1,431 men (50-80 years) with BPH/LUTS were randomly assigned to either pumpkin seed (5 g b.i.d.), capsules with pumpkin seed extract (500 mg b.i.d.) or matching placebo. The primary response criterion was a decrease in International Prostate Symptom Score (IPSS) of >= 5 points from baseline after 12 months. Secondary outcome measures included IPSS-related quality of life, IPSS single items and diary-recorded nocturia. Results: After 12 months, the response rate (intention-to-treat/last-observation-carried-forward approach) did not differ between pumpkin seed extract and placebo. In the case of pumpkin seed (responders: 58.5%), the difference compared with placebo (responders: 47.3%) was descriptively significant. The study products were well tolerated. Overall, in men with BPH, 12 months of treatment with pumpkin seed led to a clinically relevant reduction in IPSS compared with placebo. Conclusion: In order to fully justify a recommendation for the use of pumpkin seed to treat moderate LUTS, these findings need to be substantiated in a confirmatory study or systematic review. (C) 2014 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Vahlensieck, Winfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Theurer, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfitzer, Edith UNSPECIFIED UNSPECIFIED UNSPECIFIED Patz, Brigitte UNSPECIFIED UNSPECIFIED UNSPECIFIED Banik, Norbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Engelmann, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-416795
DOI:	10.1159/000362903
Journal or Publication Title:	Urol.Int.
Volume:	94
Number:	3
Page Range:	S. 286 - 296
Date:	2015
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0399
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RATS; OIL; MONOTHERAPY; EFFICACY; BPH Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41679