Universität zu Köln

Klimek, Ludger, Bachert, Claus, Mosges, Ralph, Munzel, Ullrich, Price, David, Virchow, J. Christian, Wahn, Ulrich and Bousquet, Jean (2015). Effectiveness of MP29-02 for the treatment of allergic rhinitis in real-life: Results from a noninterventional study. Allergy Asthma Proc., 36 (1). S. 40 - 48. PROVIDENCE: OCEAN SIDE PUBLICATIONS INC. ISSN 1539-6304

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Abstract

The efficacy of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) has been well established in controlled clinical trials. This study was designed to assess the use of MP29-02 and its effectiveness in routine clinical practice. This was a German multicenter, prospective, noninterventional study, including 1781 allergic rhinitis (AR) patients. Eligible patients (i.e., acute AR symptoms and visual analog scale [VAS] score >50 mm) were included, assigned MP29-02 at baseline, and reassessed after similar to 14 days. Patients assessed symptom control using a VAS from 0 (not at all bothersome) to 100 mm (very bothersome) in the morning before MP29-02 use, on days 0, 1, 3, and 7 and after similar to 14 days. Patients' perceived levels of disease control were assessed on day 3. The Youden index determined patient-reported VAS score cutoffs on day 3 for well controlled and partly controlled. MP29-02 reduced the VAS score from 75.4 mm (SD = 17.2) at baseline to 21.3 mm (SD = 18.3) by the last visit, a shift of 54.1 mm (SD = 24.6). One in every two patients felt their symptoms were well controlled at day 3. This perception of well-controlled symptoms at day 3 corresponded to an optimal VAS cutoff of 36 mm. On average, patients treated with MP29-02 crossed this well-controlled VAS cutoff by last visit. Similar results were found in adolescents, adults, and older adults, in those with perennial AR (PAR), seasonal AR (SAR), or PAR + SAR and in those with more and less severe disease. MP29-02 provides effective and rapid symptom control across all age groups in a real-life setting with responder rates higher than those observed in controlled clinical trials, supporting MP29-02's position as the drug of choice for the treatment for AR.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Klimek, Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED Bachert, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Mosges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Munzel, Ullrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Price, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Virchow, J. Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wahn, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Bousquet, Jean UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-417185
DOI:	10.2500/aap.2015.36.3823
Journal or Publication Title:	Allergy Asthma Proc.
Volume:	36
Number:	1
Page Range:	S. 40 - 48
Date:	2015
Publisher:	OCEAN SIDE PUBLICATIONS INC
Place of Publication:	PROVIDENCE
ISSN:	1539-6304
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language VISUAL ANALOG SCALE; QUALITY-OF-LIFE; MOMETASONE FUROATE; ARIA GUIDELINES; THERAPY MP29-02; PRIMARY-CARE; ASTHMA; IMPACT; EFFICACY; DESLORATADINE Multiple languages Allergy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41718