Universität zu Köln

Kaya, Yasemin, Savas, Kamil, Sarikcioglu, Levent ORCID: 0000-0002-0825-6225, Yaras, Nazmi and Angelov, Doychin N. (2015). Melatonin Leads to Axonal Regeneration, Reduction in Oxidative Stress, and Improved Functional Recovery Following Sciatic Nerve Injury. Curr. Neurovasc. Res., 12 (1). S. 53 - 63. SHARJAH: BENTHAM SCIENCE PUBL LTD. ISSN 1875-5739

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Abstract

Despite recent advances in microsurgical techniques and equipments, recovery of function following repair of transected nerves often remains suboptimal. Contrary to traumatic injuries vascular damage that causes peripheral nerve injury has not been well-documented in the literature. In the present study a total of 40 female rats were randomly divided into four groups: Group 1: intact controls (n: 10), Group 2: sham-operated (n: 10), Group 3: vehicle-treated (n: 10), Group 4: melatonin-treated (n: 10). Sciatic nerve damage was created by stripping of the epineurial vessels around the nerve. 50 mg/kg Melatonin was injected intraperitoneally immediately after epineurial stripping in Group 4 in the course of 4 postoperative weeks. We found that melatonin administration after stripping of the epineurial vessels exerted a beneficial effect on axonal regeneration and functional recovery was confirmed by functional (sensory-motor, biochemical, and electrophysiological analyses) and morphological (light microscopic and ultrastructural analyses) data. In the light of these results we concluded that melatonin in a model of sciatic nerve injury leads to axonal regeneration, reducing in oxidative stress, and improved functional recovery.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kaya, Yasemin UNSPECIFIED UNSPECIFIED UNSPECIFIED Savas, Kamil UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarikcioglu, Levent UNSPECIFIED orcid.org/0000-0002-0825-6225 UNSPECIFIED Yaras, Nazmi UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-417250
DOI:	10.2174/1567202612666150102151900
Journal or Publication Title:	Curr. Neurovasc. Res.
Volume:	12
Number:	1
Page Range:	S. 53 - 63
Date:	2015
Publisher:	BENTHAM SCIENCE PUBL LTD
Place of Publication:	SHARJAH
ISSN:	1875-5739
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELL-PROLIFERATION; PERIPHERAL-NERVES; IN-VITRO; ISCHEMIA/REPERFUSION INJURY; LYMPHOCYTE-PROLIFERATION; REPERFUSION INJURY; RADICAL SCAVENGER; ARTERY-OCCLUSION; ELECTRON-DONOR; DENTATE GYRUS Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41725