Universität zu Köln

Glatz, Martin, Buchner, Matthias, Von Bartenwerffer, Wibke, Schmid-Grendelmeier, Peter, Worm, Margitta ORCID: 0000-0002-3449-1245, Hedderich, Juergen and Foelster-Holst, Regina (2015). Malassezia spp.-specific Immunoglobulin E Level is a Marker for Severity of Atopic Dermatitis in Adults. Acta Derm.-Venereol., 95 (2). S. 191 - 197. UPPSALA: ACTA DERMATO-VENEREOLOGICA. ISSN 1651-2057

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Abstract

The significance of allergen-specific IgE as marker for severity of atopic dermatitis is controversial. The aim of this study was to determine the frequency of IgE-mediated sensitisation to food and environmental allergens in 132 children and 67 adults with atopic dermatitis, and its correlation to severity of atopic dermatitis (SCORAD). Total IgE was elevated (>100 KU/l) in 79.7% of adults and 46.8% of children. Sensitisation frequencies to allergens, particularly microbial allergens, were up to 10-fold higher in adults compared to children. Severity of atopic dermatitis correlated with elevated total IgE in adults (r=0.549, p<0.001) and children (r=0.344, p=0.005) and with Malassezia spp.-specific IgE in adults (r=0.429, p=0.007). Total IgE is a marker for severe atopic dermatitis in both age groups. Malassezia spp.-specific IgE is an important allergen-specific marker for severity of atopic dermatitis in adults.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Glatz, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Buchner, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Von Bartenwerffer, Wibke UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmid-Grendelmeier, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Worm, Margitta UNSPECIFIED orcid.org/0000-0002-3449-1245 UNSPECIFIED Hedderich, Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Foelster-Holst, Regina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-417356
DOI:	10.2340/00015555-1864
Journal or Publication Title:	Acta Derm.-Venereol.
Volume:	95
Number:	2
Page Range:	S. 191 - 197
Date:	2015
Publisher:	ACTA DERMATO-VENEREOLOGICA
Place of Publication:	UPPSALA
ISSN:	1651-2057
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALLERGEN-SPECIFIC IGE; DUST-MITE; MICROBIAL ALLERGENS; INTRINSIC FORM; FOOD ALLERGY; SCORAD INDEX; CHILDREN; SENSITIZATION; ECZEMA; FUNGAL Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41735