Universität zu Köln

Macherey, Sascha, Schlaak, Max, Doerr, Fabian, Groenke, Sabine, Heldwein, Matthias, Quaas, Alexander, Zander, Thomas and Hekmat, Khosro (2015). Surgical therapy for pulmonary metastases from malignant melanoma. Hautarzt, 66 (1). S. 65 - 72. NEW YORK: SPRINGER. ISSN 1432-1173

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Abstract

Results of previous studies question the benefits of pulmonary surgery in patients with pulmonary metastases from malignant melanoma. A systematic literature search and analysis of articles published since 1 January 2000 was carried out to investigate the advantages of metastasectomy and alternative forms of therapy. Patients reached a median survival time of 17-40 months and 5-year survival rates between 18% and 39.4% after metastasectomy. Intrathoracic recurrence occurred in 30 % of patients but could be successfully treated with re-operations in some cases. Various monoclonal antibodies are currently available and achieve a median survival time of up to 17 months. Pulmonary metastasectomy is the treatment of choice in selected patients; however, in the future the benefits should be revalidated in comparison with pharmaceuticals of the current generation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Macherey, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlaak, Max UNSPECIFIED UNSPECIFIED UNSPECIFIED Doerr, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Groenke, Sabine UNSPECIFIED UNSPECIFIED UNSPECIFIED Heldwein, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Zander, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hekmat, Khosro UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-417559
DOI:	10.1007/s00105-014-3555-z
Journal or Publication Title:	Hautarzt
Volume:	66
Number:	1
Page Range:	S. 65 - 72
Date:	2015
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1173
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROGNOSTIC-FACTORS; IMPROVED SURVIVAL; OPEN-LABEL; LUNG; BRAF; MULTICENTER; VEMURAFENIB; CANCER; SAFETY Multiple languages Dermatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/41755