Macherey, Sascha, Schlaak, Max, Doerr, Fabian, Groenke, Sabine, Heldwein, Matthias, Quaas, Alexander, Zander, Thomas and Hekmat, Khosro (2015). Surgical therapy for pulmonary metastases from malignant melanoma. Hautarzt, 66 (1). S. 65 - 72. NEW YORK: SPRINGER. ISSN 1432-1173

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Abstract

Results of previous studies question the benefits of pulmonary surgery in patients with pulmonary metastases from malignant melanoma. A systematic literature search and analysis of articles published since 1 January 2000 was carried out to investigate the advantages of metastasectomy and alternative forms of therapy. Patients reached a median survival time of 17-40 months and 5-year survival rates between 18% and 39.4% after metastasectomy. Intrathoracic recurrence occurred in 30 % of patients but could be successfully treated with re-operations in some cases. Various monoclonal antibodies are currently available and achieve a median survival time of up to 17 months. Pulmonary metastasectomy is the treatment of choice in selected patients; however, in the future the benefits should be revalidated in comparison with pharmaceuticals of the current generation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Macherey, SaschaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schlaak, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doerr, FabianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groenke, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heldwein, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaas, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zander, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hekmat, KhosroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-417559
DOI: 10.1007/s00105-014-3555-z
Journal or Publication Title: Hautarzt
Volume: 66
Number: 1
Page Range: S. 65 - 72
Date: 2015
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1432-1173
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
PROGNOSTIC-FACTORS; IMPROVED SURVIVAL; OPEN-LABEL; LUNG; BRAF; MULTICENTER; VEMURAFENIB; CANCER; SAFETYMultiple languages
DermatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41755

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