Universität zu Köln

Luening, Anna, Neugebauer, Michael, Lingen, Verena, Krest, Alexander, Stirnat, Kathrin, Deacon, Glen B., Drago, Penny R., Ott, Ingo ORCID: 0000-0002-8087-4618, Schur, Julia, Pantenburg, Ingo, Meyer, Gerd and Klein, Axel ORCID: 0000-0003-0093-9619 (2015). Platinum Diolefin Complexes - Synthesis, Structures, and Cytotoxicity. Eur. J. Inorg. Chem. (2). S. 226 - 240. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1099-0682

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Abstract

The synthesis, spectroscopy, structures and chemical reactivity of platinum(II) diolefin complexes cis-[(vertical bar(perpendicular to)vertical bar)PtCl2], cis-[(vertical bar(perpendicular to)vertical bar)PtCl(R)] and cis-[(vertical bar(perpendicular to)vertical bar)Pt(R)(2)] [vertical bar(perpendicular to)vertical bar = chelate diolefin ligand: 1,5-cyclooctadiene (COD), 1,5-dimethylocta-1,5-diene (Me2COD), norbornadiene (NBD), 1,5-hexadiene (HEX), 3-allyloxypropene (All(2)O, diallyl ether), diallylamine (All(2)NH); R = Me, Bn, C6F5, C6F4H-4 (or -5), or CC(4-Me)Ph] have been explored. The relative exchange rates of the cis-[(vertical bar(perpendicular to)vertical bar)PtCl2] complexes towards the diimine ligand diisopropyl-1,4-diazabutadiene (iPr-DAB) increased along the series COD< Me2COD< NBD< HEX< All(2)O by a factor of 4. The presumably dimeric complex [(All(2)NH)PtCl2](2) undergoes a unique rearrangement process in dimethyl sulfoxide (DMSO) solution to yield the dimeric piperazine complex [PtCl(dmso)(C6H10N)](2), which has been characterised by single-crystal XRD. For selected platinum complexes, cytotoxic effects in HT-29 colon carcinoma and MCF-7 breast cancer cell lines were evaluated. For comparison, the dicationic complexes [(COD)Pt(Bn)(L)][PF6](2) with the very labile coligands N-methyl-4,4-bipyridinium (MQ(+)) and N-methyl-1,4-pyrazinium (Mpz(+)) were added to the study. Although the hexadiene complexes [(HEX)Pt(C6F4H-4)(2)] and [(HEX)Pt(C6F4H-5)(2)] show strong cytotoxicity, the introduction of labile diolefin ligands or the labile cationic MQ(+) or Mpz(+) coligands does not generally lead to markedly increased cytotoxicity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Luening, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Neugebauer, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Lingen, Verena UNSPECIFIED UNSPECIFIED UNSPECIFIED Krest, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Stirnat, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Deacon, Glen B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drago, Penny R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, Ingo UNSPECIFIED orcid.org/0000-0002-8087-4618 UNSPECIFIED Schur, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Pantenburg, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Meyer, Gerd UNSPECIFIED UNSPECIFIED UNSPECIFIED Klein, Axel UNSPECIFIED orcid.org/0000-0003-0093-9619 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-418757
DOI:	10.1002/ejic.201402954
Journal or Publication Title:	Eur. J. Inorg. Chem.
Number:	2
Page Range:	S. 226 - 240
Date:	2015
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1099-0682
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STABILIZED PHOSPHORUS YLIDES; SPECTROSCOPIC CHARACTERISTICS; NORBORNADIENE NBD; X-RAY; NUCLEOPHILIC-ATTACK; MOLECULAR-STRUCTURE; CRYSTAL-STRUCTURES; ANTICANCER DRUGS; ALKENE COMPLEXES; CELLULAR UPTAKE Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/41875