Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Bellivier, F., Belmaker, R. H., Berk, M., Bjella, T. D., Bossini, L., Bersudsky, Y., Cheung, E. Y. W., Conell, J., Del Zompo, M., Dodd, S., Etain, B., Fagiolini, A., Frye, M. A., Fountoulakis, K. N., Garneau-Fournier, J., Gonzalez-Pinto, A., Harima, H., Hassel, S., Henry, C., Iacovides, A., Isometsa, E. T., Kapczinski, F., Kliwicki, S., Koenig, B., Krogh, R., Kunz, M., Lafer, B., Larsen, E. R., Lewitzka, U., Lopez-Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Melle, I., Monteith, S., Morken, G., Munoz, R., Nery, F. G., O'Donovan, C., Osher, Y., Pfennig, A., Quiroz, D., Ramesar, R., Rasgon, N., Reif, A., Ritter, P., Rybakowski, J. K., Sagduyu, K., Scippa, A. M., Severus, E., Simhandl, C., Stein, D. J., Strejilevich, S., Sulaiman, A. Hatim, Suominen, K., Tagata, H., Tatebayashi, Y., Torrent, C., Vieta, E., Viswanath, B., Wanchoo, M. J., Zetin, M. and Whybrow, P. C. (2015). Influence of birth cohort on age of onset cluster analysis in bipolar I disorder. Eur. Psychiat., 30 (1). ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 1778-3585

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Abstract

Purpose: Two common approaches to identify subgroups of patients with bipolar disorder are clustering methodology (mixture analysis) based on the age of onset, and a birth cohort analysis. This study investigates if a birth cohort effect will influence the results of clustering on the age of onset, using a large, international database. Methods: The database includes 4037 patients with a diagnosis of bipolar I disorder, previously collected at 36 collection sites in 23 countries. Generalized estimating equations (GEE) were used to adjust the data for country median age, and in some models, birth cohort. Model-based clustering (mixture analysis) was then performed on the age of onset data using the residuals. Clinical variables in subgroups were compared. Results: There was a strong birth cohort effect. Without adjusting for the birth cohort, three subgroups were found by clustering. After adjusting for the birth cohort or when considering only those born after 1959, two subgroups were found. With results of either two or three subgroups, the youngest subgroup was more likely to have a family history of mood disorders and a first episode with depressed polarity. However, without adjusting for birth cohort (three subgroups), family history and polarity of the first episode could not be distinguished between the middle and oldest subgroups. Conclusion: These results using international data confirm prior findings using single country data, that there are subgroups of bipolar I disorder based on the age of onset, and that there is a birth cohort effect. Including the birth cohort adjustment altered the number and characteristics of subgroups detected when clustering by age of onset. Further investigation is needed to determine if combining both approaches will identify subgroups that are more useful for research. (C) 2014 Elsevier Masson SAS. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bauer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenn, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alda, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andreassen, O. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angelopoulos, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ardau, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baethge, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bellivier, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belmaker, R. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berk, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjella, T. D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bossini, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bersudsky, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheung, E. Y. W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conell, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Zompo, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dodd, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Etain, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fagiolini, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frye, M. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fountoulakis, K. N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garneau-Fournier, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Pinto, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harima, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hassel, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henry, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iacovides, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Isometsa, E. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kapczinski, F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kliwicki, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krogh, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kunz, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lafer, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larsen, E. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lewitzka, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Jaramillo, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
MacQueen, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manchia, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marsh, W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martinez-Cengotitabengoa, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melle, I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monteith, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morken, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munoz, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nery, F. G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Donovan, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osher, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfennig, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quiroz, D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramesar, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rasgon, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reif, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritter, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rybakowski, J. K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sagduyu, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scippa, A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Severus, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simhandl, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stein, D. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strejilevich, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sulaiman, A. HatimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suominen, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tagata, H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tatebayashi, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torrent, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vieta, E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Viswanath, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wanchoo, M. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zetin, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Whybrow, P. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-418784
DOI: 10.1016/j.eurpsy.2014.10.005
Journal or Publication Title: Eur. Psychiat.
Volume: 30
Number: 1
Date: 2015
Publisher: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication: ISSY-LES-MOULINEAUX
ISSN: 1778-3585
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
AT-ONSET; MAJOR DEPRESSION; ENDOCRINE ABNORMALITIES; INCREASING RATES; FAMILY-HISTORY; EAST-GERMANY; DISTRIBUTIONS; REFUGEES; SUNLIGHT; OUTCOMESMultiple languages
PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/41878

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