Universität zu Köln

Sitnikov, Nikolay S., Sinzov, Alexander V., Allegro, Diane, Barbier, Pascale, Combes, Sebastien, Onambele, Liliane Abodo, Prokop, Aram, Schmalz, Hans-Guenther ORCID: 0000-0003-0489-1827 and Fedorov, Alexey Yu (2015). Synthesis of indole-derived allocolchicine congeners exhibiting pronounced anti-proliferative and apoptosis-inducing properties. MedChemComm, 6 (12). S. 2158 - 2163. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 2040-2511

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Abstract

Based on the natural antimitotic agent allocolchicine as a lead structure, a series of novel indole-based allocolchicine congeners was synthesized and assessed in vitro for their cytostatic properties. Several compounds exhibited potent anti-proliferative and apoptosis-inducing activity towards lymphoma cells along with low unspecific cytotoxicity. The observed activity is supposed to result from the inhibition of microtubule assembly, as indicated by the tubulin polymerisation assay.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sitnikov, Nikolay S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinzov, Alexander V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Allegro, Diane UNSPECIFIED UNSPECIFIED UNSPECIFIED Barbier, Pascale UNSPECIFIED UNSPECIFIED UNSPECIFIED Combes, Sebastien UNSPECIFIED UNSPECIFIED UNSPECIFIED Onambele, Liliane Abodo UNSPECIFIED UNSPECIFIED UNSPECIFIED Prokop, Aram UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmalz, Hans-Guenther UNSPECIFIED orcid.org/0000-0003-0489-1827 UNSPECIFIED Fedorov, Alexey Yu UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-419349
DOI:	10.1039/c5md00320b
Journal or Publication Title:	MedChemComm
Volume:	6
Number:	12
Page Range:	S. 2158 - 2163
Date:	2015
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	2040-2511
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Organic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; B-RINGS; COLCHICINE; TUBULIN; AGENTS; DERIVATIVES; INHIBITION; ANALOGS; DESIGN Multiple languages Biochemistry & Molecular Biology; Chemistry, Medicinal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/41934