Universität zu Köln

Kuepper-Nybelen, Jutta, Thuermann, Petra and Schubert, Ingrid (2014). Frequency of tetrazepam prescription: estimates for Germany. Pharmacoepidemiol. Drug Saf., 23 (12). S. 1325 - 1330. HOBOKEN: WILEY-BLACKWELL. ISSN 1099-1557

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Abstract

PurposeAuthorisation was suspended on 1 August 2013 for tetrazepam-containing medicines. The aim of the study was to assess relevance and pattern of tetrazepam use by estimating the prevalence of prescribing and to analyse prescribing indications and duration. This information is needed to generate baseline data for further evaluation of prescribing muscle relaxants. MethodsClaims data analysis (Health Insurance Sample AOK Hesse/KV Hesse, 18.75% random sample of insurants from AOK Hesse, Germany). Study population: 267787 insurants continuously insured or deceased in 2011. Prevalence estimates were standardised to the German population. To assess the quantity of prescribed tetrazepam, we applied defined daily dose (DDD) methodology with 125mg of tetrazepam as 1 DDD. The prescribing indications were analysed with a matched case-control design. ResultsIn 2011, 2.6% of the study population received at least one tetrazepam prescription (men, 2.1%; women, 3.0%). The mean prescribed dosage was 15 DDD and increased by age up to 43 DDD in women and 30 DDD in men 80years. The most frequently documented diagnoses were low-back pain (21.3%) and cervicalgia (20.3%). It appeared that the greatest difference in prevalence between tetrazepam recipients and controls was for the diagnosis Other specified disorders of muscle' (ICD: M62.8). This diagnosis was five times more prevalent in tetrazepam recipients than in controls. ConclusionTetrazepam was the most widely prescribed muscle relaxant in Germany, hence physicians may seek an alternative after its market withdrawal. However, according to treatment guidelines, muscle relaxants play only a minor role and a multimodal approach should be preferred. Copyright (c) 2014 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuepper-Nybelen, Jutta UNSPECIFIED UNSPECIFIED UNSPECIFIED Thuermann, Petra UNSPECIFIED UNSPECIFIED UNSPECIFIED Schubert, Ingrid UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-421884
DOI:	10.1002/pds.3672
Journal or Publication Title:	Pharmacoepidemiol. Drug Saf.
Volume:	23
Number:	12
Page Range:	S. 1325 - 1330
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1099-1557
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POTENTIALLY INAPPROPRIATE MEDICATIONS; SKELETAL-MUSCLE RELAXANTS; BENZODIAZEPINE ACTIVITIES; DISSOCIATES SEDATION; PRISCUS LIST Multiple languages Public, Environmental & Occupational Health; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42188