Klein, Florian, Nogueira, Lilian, Nishimura, Yoshiaki, Phad, Ganesh, West, Anthony P., Jr., Halper-Stromberg, Ariel, Horwitz, Joshua A., Gazumyan, Anna, Liu, Cassie ORCID: 0000-0003-3907-9409, Eisenreich, Thomas R., Lehmann, Clara ORCID: 0000-0002-7042-1578, Faetkenheuer, Gerd, Williams, Constance, Shingai, Masashi, Martin, Malcolm A., Bjorkman, Pamela J., Seaman, Michael S., Zolla-Pazner, Susan, Hedestam, Gunilla B. Karlsson and Nussenzweig, Michel C. (2014). Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J. Exp. Med., 211 (12). S. 2361 - 2373. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-9538

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Abstract

Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian-human immunodeficiency virus (SHIV) infection in immune-competent macaques, suggesting that the host immune response might also contribute to the control of viremia. Here, we investigate how the autologous antibody response in intact hosts can contribute to the success of immunotherapy. We find that frequently arising antibodies that normally fail to control HIV-1 infection can synergize with passively administered bNAbs by preventing the emergence of bNAb viral escape variants.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Klein, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nogueira, LilianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nishimura, YoshiakiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phad, GaneshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
West, Anthony P., Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halper-Stromberg, ArielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horwitz, Joshua A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gazumyan, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liu, CassieUNSPECIFIEDorcid.org/0000-0003-3907-9409UNSPECIFIED
Eisenreich, Thomas R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lehmann, ClaraUNSPECIFIEDorcid.org/0000-0002-7042-1578UNSPECIFIED
Faetkenheuer, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Williams, ConstanceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shingai, MasashiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin, Malcolm A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjorkman, Pamela J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seaman, Michael S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zolla-Pazner, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hedestam, Gunilla B. KarlssonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nussenzweig, Michel C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-423237
DOI: 10.1084/jem.20141050
Journal or Publication Title: J. Exp. Med.
Volume: 211
Number: 12
Page Range: S. 2361 - 2373
Date: 2014
Publisher: ROCKEFELLER UNIV PRESS
Place of Publication: NEW YORK
ISSN: 1540-9538
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
BROADLY NEUTRALIZING ANTIBODIES; SIMIAN IMMUNODEFICIENCY VIRUS; HUMORAL IMMUNE-RESPONSES; BINDING-SITE ANTIBODIES; V3 LOOP; ENVELOPE PROTEIN; RHESUS-MONKEYS; HUMANIZED MICE; TYPE-1 SF162; B-CELLSMultiple languages
Immunology; Medicine, Research & ExperimentalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42323

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