Universität zu Köln

Ghibelli, Lina and Mathur, Sanjay (2014). Biological interactions of oxide nanoparticles: The good and the evil. MRS Bull., 39 (11). S. 949 - 955. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1938-1425

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Abstract

The biological effects of engineered nanoparticles are presently a focus of interest in chemistry, biology, pharmacology, clinical medicine, and toxicology due to the enormous therapeutic and diagnostic potential that the particulate nature of nanoparticles offers for selective drug delivery and controlled release. This raises unprecedented safety issues, calling for novel paradigms to face the biocompatibility analysis of particulate (as opposed to molecular) bioactive agents that vary in shape, surface, and charge, in addition to chemical structure. This issue of MRS Bulletin focuses on the bioeffects of metal oxide nanostructures, whose high bioactivity can be exploited to design novel multifunctional devices for nanomedical applications, some of which are already undergoing testing in anticancer and antioxidant clinical trials. The ubiquitous application in research and technology of these non-biodegradable structures has evoked concerns regarding their potential hazards, due to the same chemical activities that promise nanomedical developments. A Janus-type scenario is emerging, pointing to intricate networks of beneficial and detrimental effects following the biological interactions of metal oxide nanoparticles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ghibelli, Lina UNSPECIFIED UNSPECIFIED UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-424308
DOI:	10.1557/mrs.2014.250
Journal or Publication Title:	MRS Bull.
Volume:	39
Number:	11
Page Range:	S. 949 - 955
Date:	2014
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1938-1425
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TOXICITY; FOCUS; METAL Multiple languages Materials Science, Multidisciplinary; Physics, Applied Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42430