Universität zu Köln

Bucher, Franziska, Hos, Deniz, Matthaei, Mario, Steven, Philipp, Cursiefen, Claus and Heindl, Ludwig M. (2014). Corneal Nerve Alterations After Descemet Membrane Endothelial Keratoplasty: An In Vivo Confocal Microscopy Study. Cornea, 33 (11). S. 1134 - 1140. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-4798

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Abstract

Purpose: Recent studies have identified diminishment of corneal nerves as another hallmark of Fuchs endothelial corneal dystrophy. This study aimed to analyze changes in corneal nerves after Descemet membrane endothelial keratoplasty (DMEK). Methods: Twenty-five patients were assessed for nerve alterations preoperatively and 1 week, 4 months, and 20 months after DMEK surgery. Morphology of the central subbasal nerve plexus was quantified by in vivo confocal microscopy. Results: The total nerve length (481.2 +/- 81.9 vs. 1536.0 +/- 123.8 mu m per frame, P < 0.0001), total nerve number (2.2 +/- 0.3 vs. 7.2 +/- 0.5 per frame, P < 0.0001), number of main nerve trunks (1.8 +/- 0.2 vs. 3.5 +/- 0.3 per frame, P < 0.0001), and number of nerve branches (0.5 +/- 0.2 vs. 3.7 +/- 0.4 per frame, P < 0.0001) were significantly decreased 1 week after DMEK compared with preoperative measurements. Ten months postoperatively, corneal nerves recovered to preoperative values. Central corneal sensation significantly reduced postoperatively (5.1 +/- 1.0 vs. 6.0 +/- 0.0, P = 0.001), but recovered during follow-up (10 months: 6.0 +/- 0.0). Conclusions: DMEK diminishes the density and the function of subbasal corneal nerves early after transplantation. However, a complete recovery of corneal nerve density and function up to preoperative values occurs within 4 to 10 months.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bucher, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Hos, Deniz UNSPECIFIED UNSPECIFIED UNSPECIFIED Matthaei, Mario UNSPECIFIED UNSPECIFIED UNSPECIFIED Steven, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-424868
DOI:	10.1097/ICO.0000000000000250
Journal or Publication Title:	Cornea
Volume:	33
Number:	11
Page Range:	S. 1134 - 1140
Date:	2014
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1536-4798
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FLUORESCENCE MICROSCOPY; SURGERY; INNERVATION; DYSTROPHY; KERATITIS Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42486