Universität zu Köln

Wortmann, Laura, Ilyas, Shaista, Niznansky, Daniel ORCID: 0000-0001-5740-1604, Valldor, Martin, Arroub, Karim, Berger, Nadja ORCID: 0000-0002-4435-8317, Rahme, Kamil, Holmes, Justin ORCID: 0000-0001-5087-8936 and Mathur, Sanjay (2014). Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization. ACS Appl. Mater. Interfaces, 6 (19). S. 16631 - 16643. WASHINGTON: AMER CHEMICAL SOC. ISSN 1944-8252

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Abstract

A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (840 nm) and enabled biovectorization of SiO2@Fe3O4 coreshell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UVvis, zeta-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wortmann, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Ilyas, Shaista UNSPECIFIED UNSPECIFIED UNSPECIFIED Niznansky, Daniel UNSPECIFIED orcid.org/0000-0001-5740-1604 UNSPECIFIED Valldor, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Arroub, Karim UNSPECIFIED UNSPECIFIED UNSPECIFIED Berger, Nadja UNSPECIFIED orcid.org/0000-0002-4435-8317 UNSPECIFIED Rahme, Kamil UNSPECIFIED UNSPECIFIED UNSPECIFIED Holmes, Justin UNSPECIFIED orcid.org/0000-0001-5087-8936 UNSPECIFIED Mathur, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-425851
DOI:	10.1021/am503068r
Journal or Publication Title:	ACS Appl. Mater. Interfaces
Volume:	6
Number:	19
Page Range:	S. 16631 - 16643
Date:	2014
Publisher:	AMER CHEMICAL SOC
Place of Publication:	WASHINGTON
ISSN:	1944-8252
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Inorganic Chemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FOLIC-ACID; ALPHA-FE2O3 NANOPARTICLES; MAGNETITE NANOPARTICLES; SILICA NANOPARTICLES; CLICK-CHEMISTRY; RECENT PROGRESS; CANCER; TOXICITY; CELLS; IMMOBILIZATION Multiple languages Nanoscience & Nanotechnology; Materials Science, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42585