Wortmann, Laura, Ilyas, Shaista, Niznansky, Daniel ORCID: 0000-0001-5740-1604, Valldor, Martin, Arroub, Karim, Berger, Nadja ORCID: 0000-0002-4435-8317, Rahme, Kamil, Holmes, Justin ORCID: 0000-0001-5087-8936 and Mathur, Sanjay (2014). Bioconjugated Iron Oxide Nanocubes: Synthesis, Functionalization, and Vectorization. ACS Appl. Mater. Interfaces, 6 (19). S. 16631 - 16643. WASHINGTON: AMER CHEMICAL SOC. ISSN 1944-8252

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Abstract

A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (840 nm) and enabled biovectorization of SiO2@Fe3O4 coreshell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UVvis, zeta-potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Wortmann, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ilyas, ShaistaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niznansky, DanielUNSPECIFIEDorcid.org/0000-0001-5740-1604UNSPECIFIED
Valldor, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arroub, KarimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, NadjaUNSPECIFIEDorcid.org/0000-0002-4435-8317UNSPECIFIED
Rahme, KamilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holmes, JustinUNSPECIFIEDorcid.org/0000-0001-5087-8936UNSPECIFIED
Mathur, SanjayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-425851
DOI: 10.1021/am503068r
Journal or Publication Title: ACS Appl. Mater. Interfaces
Volume: 6
Number: 19
Page Range: S. 16631 - 16643
Date: 2014
Publisher: AMER CHEMICAL SOC
Place of Publication: WASHINGTON
ISSN: 1944-8252
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FOLIC-ACID; ALPHA-FE2O3 NANOPARTICLES; MAGNETITE NANOPARTICLES; SILICA NANOPARTICLES; CLICK-CHEMISTRY; RECENT PROGRESS; CANCER; TOXICITY; CELLS; IMMOBILIZATIONMultiple languages
Nanoscience & Nanotechnology; Materials Science, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/42585

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