Universität zu Köln

Hartmann, Sylvia, Eichenauer, Dennis A., Pluetschow, Annette, Mottok, Anja ORCID: 0000-0003-3125-0494, Bob, Roshanak, Koch, Karoline, Bernd, Heinz-Wolfram, Cogliatti, Sergio, Hummel, Michael, Feller, Alfred C., Ott, German, Moeller, Peter, Rosenwald, Andreas, Stein, Harald, Hansmann, Martin-Leo, Engert, Andreas and Klapper, Wolfram (2014). Histopathological features and their prognostic impact in nodular lymphocyte-predominant Hodgkin lymphoma - a matched pair analysis from the German Hodgkin Study Group (GHSG). Br. J. Haematol., 167 (2). S. 238 - 243. HOBOKEN: WILEY-BLACKWELL. ISSN 1365-2141

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Abstract

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma entity. We performed a matched-pair analysis to evaluate the prognostic impact of several histopathological features in this distinct Hodgkin lymphoma subtype. Lymph node samples of NLPHL patients were tested for CD15, IgD, phosphorylated STAT6, ICOS and Epstein-Barr virus status of the malignant lymphocyte-predominant cells as well as epithelioid cell clusters and activated T cells in the microenvironment. None of these features was associated with a particular clinical outcome. However, patients presenting with epithelioid cell clusters showed a non-significant trend towards a lower relapse rate, justifying further evaluation of this marker.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hartmann, Sylvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Eichenauer, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pluetschow, Annette UNSPECIFIED UNSPECIFIED UNSPECIFIED Mottok, Anja UNSPECIFIED orcid.org/0000-0003-3125-0494 UNSPECIFIED Bob, Roshanak UNSPECIFIED UNSPECIFIED UNSPECIFIED Koch, Karoline UNSPECIFIED UNSPECIFIED UNSPECIFIED Bernd, Heinz-Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED Cogliatti, Sergio UNSPECIFIED UNSPECIFIED UNSPECIFIED Hummel, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Feller, Alfred C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ott, German UNSPECIFIED UNSPECIFIED UNSPECIFIED Moeller, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosenwald, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Stein, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Hansmann, Martin-Leo UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Klapper, Wolfram UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-427319
DOI:	10.1111/bjh.12997
Journal or Publication Title:	Br. J. Haematol.
Volume:	167
Number:	2
Page Range:	S. 238 - 243
Date:	2014
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1365-2141
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CELLS; RITUXIMAB; PHENOTYPE; SOCS1 Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/42731