Kumari, Snehlata, Herzberg, Benjamin, Pofahl, Ruth, Krieg, Thomas and Haase, Ingo (2014). Epidermal RelA Specifically Restricts Contact Allergen-Induced Inflammation and Apoptosis in Skin. J. Invest. Dermatol., 134 (10). S. 2541 - 2551. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1523-1747
Full text not available from this repository.Abstract
Strong inhibition of NF-kappa B signaling in the epidermis results in spontaneous skin inflammation in mice and men. As there is evidence for linkage between polymorphisms within the NF-kappa B signaling pathway and human inflammatory skin phenotypes, we asked whether partial functional inhibition of NF-kappa B signaling in epidermal keratinocytes can modulate clinically relevant skin inflammation. We therefore mutated rela specifically in the epidermis of mice (RelA(E-MUT) mice). These mice show no inflammatory phenotype. Induction of contact allergy, but not croton oil-induced irritant dermatitis, resulted in stronger ear swelling and increased epidermal thickness in RelA(E-MUT) mice. Both contact allergen and croton oil treatment led to increased expression of calgranulins A and B (S100A8/A9) in RelA(E-MUT) mice. Epidermal hyperproliferation in RelA(E-MUT) mice was non-cell autonomous as cultured primary epidermal keratinocytes from RelA(E-MUT) mice showed reduced proliferation compared with controls. These results demonstrate that epidermal RelA specifically regulates delayed-type hypersensitivity-induced skin inflammation. In addition, we describe here an essential but nonspecific function of RelA in the protection of epidermal keratinocytes from apoptosis. Our study identifies functions of NF-kappa B signaling in the epidermis and corroborates a specific role of epidermal keratinocytes in the regulation of skin inflammation.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-428149 | ||||||||||||||||||||||||
DOI: | 10.1038/jid.2014.193 | ||||||||||||||||||||||||
Journal or Publication Title: | J. Invest. Dermatol. | ||||||||||||||||||||||||
Volume: | 134 | ||||||||||||||||||||||||
Number: | 10 | ||||||||||||||||||||||||
Page Range: | S. 2541 - 2551 | ||||||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||||||
Publisher: | NATURE PUBLISHING GROUP | ||||||||||||||||||||||||
Place of Publication: | NEW YORK | ||||||||||||||||||||||||
ISSN: | 1523-1747 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/42814 |
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