Universität zu Köln

Nowak, Stefan, Neidhart, Johannes, Szendro, Ivan G. and Krug, Joachim ORCID: 0000-0002-2143-6490 (2014). Multidimensional Epistasis and the Transitory Advantage of Sex. PLoS Comput. Biol., 10 (9). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7358

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Abstract

Identifying and quantifying the benefits of sex and recombination is a long-standing problem in evolutionary theory. In particular, contradictory claims have been made about the existence of a benefit of recombination on high dimensional fitness landscapes in the presence of sign epistasis. Here we present a comparative numerical study of sexual and asexual evolutionary dynamics of haploids on tunably rugged model landscapes under strong selection, paying special attention to the temporal development of the evolutionary advantage of recombination and the link between population diversity and the rate of adaptation. We show that the adaptive advantage of recombination on static rugged landscapes is strictly transitory. At early times, an advantage of recombination arises through the possibility to combine individually occurring beneficial mutations, but this effect is reversed at longer times by the much more efficient trapping of recombining populations at local fitness peaks. These findings are explained by means of well-established results for a setup with only two loci. In accordance with the Red Queen hypothesis the transitory advantage can be prolonged indefinitely in fluctuating environments, and it is maximal when the environment fluctuates on the same time scale on which trapping at local optima typically occurs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Nowak, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Neidhart, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Szendro, Ivan G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED orcid.org/0000-0002-2143-6490 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-429765
DOI:	10.1371/journal.pcbi.1003836
Journal or Publication Title:	PLoS Comput. Biol.
Volume:	10
Number:	9
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1553-7358
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EMPIRICAL FITNESS LANDSCAPES; EVOLUTIONARY ACCESSIBILITY; ADAPTIVE WALKS; ADAPTATION; MODEL; RECOMBINATION; SELECTION; LINKAGE; MUTATION; PEAKS Multiple languages Biochemical Research Methods; Mathematical & Computational Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/42976