Nosseir, N. S., Michels, G., Pfister, R., Adam, R., Wiesen, M. H. J. and Mueller, C. (2014). Therapeutic Drug Monitoring of antiinfectives in intensive care medicine. Dtsch. Med. Wochenschr., 139 (38). S. 1889 - 1895. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4413
Full text not available from this repository.Abstract
Therapeutic Drug Monitoring (TDM) is based on drug-level control in biological matrices and serves as a diagnostic approach for individualization of pharmacotherapy and drug safety. Drug levels of antibiotics are distinctly influenced by comorbidity, physiological changes and various concomitant drugs in patients on intensive care units. Several factors should be taken into account for calculation of relevant pharmacokinetic parameters (elimination half-life, bioavailability, and clearance) to deduce a recommendation for dosage. TDM is a diagnostic standard for the individualization of polypharmcotherapy based on validated analytical methods (in particular LC-MS/MS and HPLC-methods) in order to optimize dosing and drug safety.
Item Type: | Journal Article | ||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-429990 | ||||||||||||||||||||||||||||
DOI: | 10.1055/s-0034-1387215 | ||||||||||||||||||||||||||||
Journal or Publication Title: | Dtsch. Med. Wochenschr. | ||||||||||||||||||||||||||||
Volume: | 139 | ||||||||||||||||||||||||||||
Number: | 38 | ||||||||||||||||||||||||||||
Page Range: | S. 1889 - 1895 | ||||||||||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||||||||||
Publisher: | GEORG THIEME VERLAG KG | ||||||||||||||||||||||||||||
Place of Publication: | STUTTGART | ||||||||||||||||||||||||||||
ISSN: | 1439-4413 | ||||||||||||||||||||||||||||
Language: | German | ||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/42999 |
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