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Fauser, Sascha, Schwabecker, Viktoria and Muether, Philipp S. (2014). Suppression of Intraocular Vascular Endothelial Growth Factor During Aflibercept Treatment of Age-Related Macular Degeneration. Am. J. Ophthalmol., 158 (3). S. 532 - 537. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1879-1891

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Abstract

PURPOSE: To determine the duration of suppression of aqueous humor concentrations of vascular endothelial growth factor (VEGF) in eyes with neovascular age-related macular degeneration (AMD) treated with aflibercept. DESIGN: Nonrandomized prospective clinical study. METHODS: Twenty-seven eyes of 27 neovascular AMD patients receiving intravitreal aflibercept injections on a pro re nata regimen driven by spectral-domain optical coherence tomography (SD OCT) were included in this study. A total of 132 aqueous humor specimens were collected before intravitreal aflibercept injections and their VEGF-A concentrations assayed by multiplex bead analysis. RESULTS: Mean aqueous humor VEGF concentrations before treatment initiation were 90.6 +/- 37.1 pg/mL (range 23.4-190.3 pg/mL). Intravitreal injection of aflibercept suppressed the aqueous VEGF concentrations to below the lower limit of quantification (< 4 pg/mL) in all patients. The mean duration of VEGF suppression below the lower limit of quantification was >71 +/- 18 days. The earliest time after injection at which the VEGF concentration recovered to above the lower limit of quantification was 55 days in 1 patient and >56 days, the recommended aflibercept treatment interval, in 20 patients. The aqueous VEGF recovery status of 6 patients was uncertain after 56 days. CONCLUSIONS: On average, VEGF concentrations in the aqueous humor were suppressed below the lower limit of quantification after intravitreal aflibercept injections for about 10 weeks. This aqueous suppression time suggests durable VEGF inhibition for most patients dosed with aflibercept every 8 weeks. (C) 2014 by Elsevier Inc. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwabecker, Viktoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Muether, Philipp S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-430573
DOI:	10.1016/j.ajo.2014.05.025
Journal or Publication Title:	Am. J. Ophthalmol.
Volume:	158
Number:	3
Page Range:	S. 532 - 537
Date:	2014
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1879-1891
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language AQUEOUS-HUMOR LEVELS; VEGF TRAP; VITREOUS LEVELS; RANIBIZUMAB; BEVACIZUMAB; CYTOKINES Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43057