Universität zu Köln

Eckes, Beate, Moinzadeh, Pia, Sengle, Gerhard, Hunzelmann, Nico and Krieg, Thomas (2014). Molecular and cellular basis of scleroderma. J. Mol. Med., 92 (9). S. 913 - 925. NEW YORK: SPRINGER. ISSN 1432-1440

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Abstract

Systemic sclerosis (scleroderma) is a chronic inflammatory disease that leads to fibrosis of the skin and involved internal organs. No efficient therapy is currently available. This review summarizes recent progress made in basic as well as clinical science and concludes with a concept that therapy targeting fibrosis in scleroderma needs to take into account the global microenvironment in the skin with its diverse cellular players interacting with a complex extracellular matrix environment and matrix-associated growth factors.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eckes, Beate UNSPECIFIED UNSPECIFIED UNSPECIFIED Moinzadeh, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Sengle, Gerhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Hunzelmann, Nico UNSPECIFIED UNSPECIFIED UNSPECIFIED Krieg, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-430645
DOI:	10.1007/s00109-014-1190-x
Journal or Publication Title:	J. Mol. Med.
Volume:	92
Number:	9
Page Range:	S. 913 - 925
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1440
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CUTANEOUS SYSTEMIC-SCLEROSIS; GENOME-WIDE ASSOCIATION; GROWTH-FACTOR RECEPTOR; CONNECTIVE-TISSUE; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; STIMULATORY AUTOANTIBODIES; DISEASE SCLERODERMA; STRUCTURAL-ANALYSIS; COLLAGEN-SYNTHESIS Multiple languages Genetics & Heredity; Medicine, Research & Experimental Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43064