Universität zu Köln

Heinzel, Alexander ORCID: 0000-0002-2430-4557, Mueller, Dirk, Behrendt, Florian F., Giovanella, Luca, Mottaghy, Felix M. and Verburg, Frederik A. (2014). Thyroid nodules with indeterminate cytology: molecular imaging with Tc-99m-methoxyisobutylisonitrile (MIBI) is more cost-effective than the AfirmaA (R) gene expression classifier. Eur. J. Nucl. Med. Mol. Imaging, 41 (8). S. 1497 - 1501. NEW YORK: SPRINGER. ISSN 1619-7089

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Abstract

Purpose To compare the cost-effectiveness of Tc-99m-methoxyisobutylisonitrile (MIBI) thyroid scintigraphy and the AfirmaA (R) gene expression classifier for the assessment of cytologically indeterminate thyroid nodules. Methods A decision tree model was used. Costs were calculated from the perspective of the German health insurance system. The robustness of the results was assessed with probabilistic sensitivity analyses using a Monte Carlo simulation. Results Life expectancy was 34.3 years (estimated costs per patient a,not sign1,459 - a,not sign2,224) for the MIBI scan and 34.1 years (estimated costs a,not sign3,560 - a,not sign4,071) for the molecular test. These results were confirmed by the Monte Carlo simulation. Conclusion MIBI thyroid scintigraphy is more cost-effective than the gene expression classifier.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heinzel, Alexander UNSPECIFIED orcid.org/0000-0002-2430-4557 UNSPECIFIED Mueller, Dirk UNSPECIFIED UNSPECIFIED UNSPECIFIED Behrendt, Florian F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Giovanella, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Mottaghy, Felix M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Verburg, Frederik A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-433266
DOI:	10.1007/s00259-014-2760-4
Journal or Publication Title:	Eur. J. Nucl. Med. Mol. Imaging
Volume:	41
Number:	8
Page Range:	S. 1497 - 1501
Date:	2014
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1619-7089
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASPIRATION-CYTOLOGY; MALIGNANCY; SCINTIGRAPHY; TC-99M-MIBI Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43326