Universität zu Köln

Cardenas-Morales, Lizbeth, Volz, Lukas J. ORCID: 0000-0002-0161-654X, Michely, Jochen, Rehme, Anne K., Pool, Eva-Maria ORCID: 0000-0001-8007-9588, Nettekoven, Charlotte ORCID: 0000-0002-8944-4681, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian ORCID: 0000-0002-1656-720X (2014). Network Connectivity and Individual Responses to Brain Stimulation in the Human Motor System. Cereb. Cortex, 24 (7). S. 1697 - 1708. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

The mechanisms driving cortical plasticity in response to brain stimulation are still incompletely understood. We here explored whether neural activity and connectivity in the motor system relate to the magnitude of cortical plasticity induced by repetitive transcranial magnetic stimulation (rTMS). Twelve right-handed volunteers underwent functional magnetic resonance imaging during rest and while performing a simple hand motor task. Resting-state functional connectivity, task-induced activation, and task-related effective connectivity were assessed for a network of key motor areas. We then investigated the effects of intermittent theta-burst stimulation (iTBS) on motor-evoked potentials (MEP) for up to 25 min after stimulation over left primary motor cortex (M1) or parieto-occipital vertex (for control). ITBS-induced increases in MEP amplitudes correlated negatively with movement-related fMRI activity in left M1. Control iTBS had no effect on M1 excitability. Subjects with better response to M1-iTBS featured stronger preinterventional effective connectivity between left premotor areas and left M1. In contrast, resting-state connectivity did not predict iTBS aftereffects. Plasticity-related changes in M1 following brain stimulation seem to depend not only on local factors but also on interconnected brain regions. Predominantly activity-dependent properties of the cortical motor system are indicative of excitability changes following induction of cortical plasticity with rTMS.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cardenas-Morales, Lizbeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Volz, Lukas J. UNSPECIFIED orcid.org/0000-0002-0161-654X UNSPECIFIED Michely, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Rehme, Anne K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pool, Eva-Maria UNSPECIFIED orcid.org/0000-0001-8007-9588 UNSPECIFIED Nettekoven, Charlotte UNSPECIFIED orcid.org/0000-0002-8944-4681 UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED Fink, Gereon R. UNSPECIFIED orcid.org/0000-0002-8230-1856 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED
URN:	urn:nbn:de:hbz:38-435220
DOI:	10.1093/cercor/bht023
Journal or Publication Title:	Cereb. Cortex
Volume:	24
Number:	7
Page Range:	S. 1697 - 1708
Date:	2014
Publisher:	OXFORD UNIV PRESS INC
Place of Publication:	CARY
ISSN:	1460-2199
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language THETA-BURST-STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; VENTRAL PREMOTOR CORTEX; LONG-TERM POTENTIATION; CORTICAL PLASTICITY; CORTICOCORTICAL CONNECTIONS; FUNCTIONAL CONNECTIVITY; PHYSIOLOGICAL-BASIS; STROKE PATIENTS; MACAQUE MONKEY Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43522