Cardenas-Morales, Lizbeth, Volz, Lukas J. ORCID: 0000-0002-0161-654X, Michely, Jochen, Rehme, Anne K., Pool, Eva-Maria ORCID: 0000-0001-8007-9588, Nettekoven, Charlotte ORCID: 0000-0002-8944-4681, Eickhoff, Simon B. ORCID: 0000-0001-6363-2759, Fink, Gereon R. ORCID: 0000-0002-8230-1856 and Grefkes, Christian ORCID: 0000-0002-1656-720X (2014). Network Connectivity and Individual Responses to Brain Stimulation in the Human Motor System. Cereb. Cortex, 24 (7). S. 1697 - 1708. CARY: OXFORD UNIV PRESS INC. ISSN 1460-2199

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Abstract

The mechanisms driving cortical plasticity in response to brain stimulation are still incompletely understood. We here explored whether neural activity and connectivity in the motor system relate to the magnitude of cortical plasticity induced by repetitive transcranial magnetic stimulation (rTMS). Twelve right-handed volunteers underwent functional magnetic resonance imaging during rest and while performing a simple hand motor task. Resting-state functional connectivity, task-induced activation, and task-related effective connectivity were assessed for a network of key motor areas. We then investigated the effects of intermittent theta-burst stimulation (iTBS) on motor-evoked potentials (MEP) for up to 25 min after stimulation over left primary motor cortex (M1) or parieto-occipital vertex (for control). ITBS-induced increases in MEP amplitudes correlated negatively with movement-related fMRI activity in left M1. Control iTBS had no effect on M1 excitability. Subjects with better response to M1-iTBS featured stronger preinterventional effective connectivity between left premotor areas and left M1. In contrast, resting-state connectivity did not predict iTBS aftereffects. Plasticity-related changes in M1 following brain stimulation seem to depend not only on local factors but also on interconnected brain regions. Predominantly activity-dependent properties of the cortical motor system are indicative of excitability changes following induction of cortical plasticity with rTMS.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Cardenas-Morales, LizbethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volz, Lukas J.UNSPECIFIEDorcid.org/0000-0002-0161-654XUNSPECIFIED
Michely, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rehme, Anne K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pool, Eva-MariaUNSPECIFIEDorcid.org/0000-0001-8007-9588UNSPECIFIED
Nettekoven, CharlotteUNSPECIFIEDorcid.org/0000-0002-8944-4681UNSPECIFIED
Eickhoff, Simon B.UNSPECIFIEDorcid.org/0000-0001-6363-2759UNSPECIFIED
Fink, Gereon R.UNSPECIFIEDorcid.org/0000-0002-8230-1856UNSPECIFIED
Grefkes, ChristianUNSPECIFIEDorcid.org/0000-0002-1656-720XUNSPECIFIED
URN: urn:nbn:de:hbz:38-435220
DOI: 10.1093/cercor/bht023
Journal or Publication Title: Cereb. Cortex
Volume: 24
Number: 7
Page Range: S. 1697 - 1708
Date: 2014
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1460-2199
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
THETA-BURST-STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION; VENTRAL PREMOTOR CORTEX; LONG-TERM POTENTIATION; CORTICAL PLASTICITY; CORTICOCORTICAL CONNECTIONS; FUNCTIONAL CONNECTIVITY; PHYSIOLOGICAL-BASIS; STROKE PATIENTS; MACAQUE MONKEYMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43522

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