Universität zu Köln

de Visser, J. Arjan G. M. and Krug, Joachim ORCID: 0000-0002-2143-6490 (2014). Empirical fitness landscapes and the predictability of evolution. Nat. Rev. Genet., 15 (7). S. 480 - 491. LONDON: NATURE PUBLISHING GROUP. ISSN 1471-0064

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Abstract

The genotype-fitness map (that is, the fitness landscape) is a key determinant of evolution, yet it has mostly been used as a superficial metaphor because we know little about its structure. This is now changing, as real fitness landscapes are being analysed by constructing genotypes with all possible combinations of small sets of mutations observed in phylogenies or in evolution experiments. In turn, these first glimpses of empirical fitness landscapes inspire theoretical analyses of the predictability of evolution. Here, we review these recent empirical and theoretical developments, identify methodological issues and organizing principles, and discuss possibilities to develop more realistic fitness landscape models.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code de Visser, J. Arjan G. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Krug, Joachim UNSPECIFIED orcid.org/0000-0002-2143-6490 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-435419
DOI:	10.1038/nrg3744
Journal or Publication Title:	Nat. Rev. Genet.
Volume:	15
Number:	7
Page Range:	S. 480 - 491
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1471-0064
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BENEFICIAL MUTATIONS; DELETERIOUS MUTATIONS; SEQUENCE SPACE; SIGN EPISTASIS; SELECTION; MODEL; RNA; ADAPTATION; GENOTYPE; EVOLVABILITY Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/43541