El Majdoub, Faycal, Rezk, Essam ORCID: 0000-0002-1290-5478, Hunsche, Stefan, Buehrle, Christian, Sturm, Volker and Maarouf, Mohammad (2014). Intracranial ganglioglioma WHO I: results in a series of eight patients treated with stereotactic interstitial brachytherapy. J. Neuro-Oncol., 118 (2). S. 345 - 351. NEW YORK: SPRINGER. ISSN 1573-7373

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In this retrospective study we evaluated the efficacy of interstitial brachytherapy (IBT) using (125)Iodine seeds (I-125) for intracranial ganglioglioma WHO I. Between October 1994 and March 2010, eight patients (m/f = 5/3, median age 30.4 years, age range 7-42.5 years) with intracranial ganglioglioma WHO I were treated with IBT using stereotactically implanted I-125 seeds. The median follow-up time was 41.5 months (range 16.7-140.1 months). Prior to interstitial brachytherapy one patient underwent microsurgical resection for three times; seven patients were treated with IBT primarily. In all patients we implanted the I-125 seeds stereotactically guided. The cumulative tumor surface dose ranged between 50 and 65 Gy (permanent implantation) and the median tumor volume was 5.6 ml (range 0.9-26 ml). After brachytherapy, follow-up MR imaging revealed complete remission in one patient, partial remission in three and stable disease in the remaining four patients. Five of eight patients presented with seizures were either seizure-free (1/5) or improved (4/5). Temporary treatment-related morbidity occurred in one patient only (headache, nausea/vomiting) and resolved completely under steroid medication after 4 weeks. No treatment-related mortality was observed. This study indicates that interstitial brachytherapy for the treatment of intracranial ganglioglioma WHO I is safe and provides a high rate of local tumor control. Due to the limited number of cases, it is not possible to conduct a rigorous statistical evaluation. Thus, larger numbers of patients are required.

Item Type: Journal Article
CreatorsEmailORCIDORCID Put Code
Rezk, EssamUNSPECIFIEDorcid.org/0000-0002-1290-5478UNSPECIFIED
URN: urn:nbn:de:hbz:38-436964
DOI: 10.1007/s11060-014-1438-x
Journal or Publication Title: J. Neuro-Oncol.
Volume: 118
Number: 2
Page Range: S. 345 - 351
Date: 2014
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1573-7373
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
TUMORS; MRIMultiple languages
Oncology; Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/43696


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