Universität zu Köln

Eichenauer, Dennis A., Boell, Boris and Diehl, Volker (2014). Pharmacotherapy of Hodgkin lymphoma: standard approaches and future perspectives. Expert Opin. Pharmacother., 15 (8). S. 1139 - 1152. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-7666

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Abstract

Introduction: Hodgkin lymphoma (HL) is a lymphoid malignancy with an incidence of 2 - 3/100,000/year. Young adults are most often affected. Due to the development of highly active multi-agent chemotherapy protocols and the optimization of radiotherapy (RT) fields and doses, HL has become one of the malignancies with the highest cure rates. As treatment efficacy can hardly be improved, the major goal of clinical HL research consists in decreasing therapy-associated acute and long-term toxicity. To this end, treatment stratification based on interim positron emission tomography and the implementation of targeted drugs such as the antibody-drug conjugate brentuximab vedotin are currently being evaluated in prospective trials. Areas covered: This article reviews recent randomized Phase III and larger Phase II trials including HL patients. Expert opinion: In early stage HL, excellent results are achieved with a brief chemotherapy followed by involved-field RT. Patients with advanced HL should receive six to eight cycles of chemotherapy optionally followed by localized RT. In relapsed disease, high-dose chemotherapy followed by autologous stem cell transplantation represents the standard of care for most patients. The use of novel drugs and imaging tools that currently undergo evaluation may optimize HL treatment.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Eichenauer, Dennis A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boell, Boris UNSPECIFIED UNSPECIFIED UNSPECIFIED Diehl, Volker UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437034
DOI:	10.1517/14656566.2014.909411
Journal or Publication Title:	Expert Opin. Pharmacother.
Volume:	15
Number:	8
Page Range:	S. 1139 - 1152
Date:	2014
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-7666
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL TRANSPLANTATION; EXTENDED-FIELD RADIOTHERAPY; HIGH-DOSE CHEMOTHERAPY; TERM-FOLLOW-UP; BRENTUXIMAB VEDOTIN; ELDERLY-PATIENTS; RETROSPECTIVE ANALYSIS; COMPREHENSIVE ANALYSIS; OLDER PATIENTS; FINAL ANALYSIS Multiple languages Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43703