Universität zu Köln

Hitz, Stefan, Habekost, Cornelia, Fuerst, Sebastian, Delso, Gaspar ORCID: 0000-0003-0438-8244, Foerster, Stefan, Ziegler, Sibylle, Nekolla, Stephan G., Souvatzoglou, Michael, Beer, Ambros J., Grimmer, Timo, Eiber, Matthias, Schwaiger, Markus and Drzezga, Alexander (2014). Systematic Comparison of the Performance of Integrated Whole-Body PET/MR Imaging to Conventional PET/CT for F-18-FDG Brain Imaging in Patients Examined for Suspected Dementia. J. Nucl. Med., 55 (6). S. 923 - 932. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

Technologic specifications of recently introduced integrated PET/MR instrumentation, such as MR-based attenuation correction, may particularly affect brain imaging procedures. To evaluate the qualitative performance of PET/MR in clinical neuroimaging, we systematically compared results obtained with integrated PET/MR with conventional PET/CT in the same patients examined for assessment of cognitive impairment. Methods: Thirty patients underwent a single-injection (F-18-FDG), dual-imaging protocol including PET/CT and integrated PET/MR imaging in randomized order. Attenuation and scatter correction were performed using low-dose CT for the PET/CT and segmented Dixon MR imaging data for the PET/MR. Differences between PET/MR and PET/CT were assessed via region-of-interest (ROI) based and voxel-based statistical group comparison. Analyses involved attenuation-corrected (AC) and non attenuation-corrected (NAC) data. Individual PET/MR and PET/CT datasets were compared versus a predefined independent control population, using 3-dimensional stereotactic surface projections. Results: Generally, lower measured PET signal values were obtained throughout the brain in ROI-based quantification of the PET signal for PET/MR as compared with PET/CT in AC and NAC data, independently of the scan order. After elimination of global effects, voxel-based and ROI-based group comparison still revealed significantly lower relative tracer signal in PET/MR images in frontoparietal portions of the neocortex but significantly higher relative signal in subcortical and basal regions of the brain than the corresponding PET/CT images of the AC data. In the corresponding NAC images, the discrepancies in frontoparietal portions of the neocortex were diminished, but the subcortical overestimation of tracer intensity by PET/MR persisted. Conclusion: Considerable region-dependent differences were observed between brain imaging data acquired on the PET/MR, compared with corresponding PET/CT images, in patients evaluated for neurodegenerative disorders. These findings may only in part be explained by inconsistencies in the attenuation-correction procedures. The observed differences may interfere with semiquantitative evaluation and with individual qualitative clinical assessment and they need to be considered, for example, for clinical trials. Improved attenuation-correction algorithms and a PET/MR-specific healthy control database are recommended for reliable and consistent application of PET/MR for clinical neuroimaging.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hitz, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Habekost, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuerst, Sebastian UNSPECIFIED UNSPECIFIED UNSPECIFIED Delso, Gaspar UNSPECIFIED orcid.org/0000-0003-0438-8244 UNSPECIFIED Foerster, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Ziegler, Sibylle UNSPECIFIED UNSPECIFIED UNSPECIFIED Nekolla, Stephan G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Souvatzoglou, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Beer, Ambros J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Eiber, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwaiger, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437071
DOI:	10.2967/jnumed.113.126813
Journal or Publication Title:	J. Nucl. Med.
Volume:	55
Number:	6
Page Range:	S. 923 - 932
Date:	2014
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; ULTRASHORT ECHO TIME; ALZHEIMERS-DISEASE; ATTENUATION-CORRECTION; MRI; DIAGNOSIS; SCANNER; REGISTRATION; SEQUENCES Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43707