Universität zu Köln

Rinschen, Markus M., Schermer, Bernhard ORCID: 0000-0002-5194-9000 and Benzing, Thomas (2014). Vasopressin-2 Receptor Signaling and Autosomal Dominant Polycystic Kidney Disease: From Bench to Bedside and Back Again. J. Am. Soc. Nephrol., 25 (6). S. 1140 - 1148. WASHINGTON: AMER SOC NEPHROLOGY. ISSN 1533-3450

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Abstract

Blockade of the vasopressin-2 receptor (V2R) in the kidney has recently emerged as a promising therapeutic strategy in autosomal dominant polycystic kidney disease. The pathophysiologic basis of V2R-dependent cyst proliferation and disease progression, however, is not fully understood. Recent evidence suggests that polycystic kidney disease is characterized by defects in urinary concentrating mechanisms and subsequent deregulation of vasopressin excretion by the neurohypophysis. On the cellular level, several recent studies revealed unexpected crosstalk of signaling pathways downstream of V2R activation in the kidney epithelium. This review summarizes some of the unexpected roles of V2R signaling and suggests that vasopressin signaling itself may contribute crucially to loss of polarity and enhanced proliferation in cystic kidney epithelium.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rinschen, Markus M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schermer, Bernhard UNSPECIFIED orcid.org/0000-0002-5194-9000 UNSPECIFIED Benzing, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437098
DOI:	10.1681/ASN.2013101037
Journal or Publication Title:	J. Am. Soc. Nephrol.
Volume:	25
Number:	6
Page Range:	S. 1140 - 1148
Date:	2014
Publisher:	AMER SOC NEPHROLOGY
Place of Publication:	WASHINGTON
ISSN:	1533-3450
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RENAL COLLECTING DUCT; THICK ASCENDING LIMB; PROTEIN-KINASE-A; BETA-CATENIN; CONCENTRATING CAPACITY; WATER PERMEABILITY; CELL-PROLIFERATION; SURROGATE MARKER; CAMP PRODUCTION; STABLE PEPTIDE Multiple languages Urology & Nephrology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43709