Universität zu Köln

Hoffstaedter, Felix ORCID: 0000-0001-7163-3110, Grefkes, Christian ORCID: 0000-0002-1656-720X, Caspers, Svenja ORCID: 0000-0001-5083-4669, Roski, Christian, Palomero-Gallagher, Nicola ORCID: 0000-0003-4463-8578, Laird, Angie R., Fox, Peter T. and Eickhoff, Simon B. ORCID: 0000-0001-6363-2759 (2014). The Role of Anterior Midcingulate Cortex in Cognitive Motor Control: Evidence From Functional Connectivity Analyses. Hum. Brain Mapp., 35 (6). S. 2741 - 2754. HOBOKEN: WILEY. ISSN 1097-0193

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Abstract

The rostral cingulate cortex has been associated with a multitude of cognitive control functions. Recent neuroimaging data suggest that the anterior midcingulate cortex (aMCC) has a key role for cognitive aspects of movement generation, i.e., intentional motor control. We here tested the functional connectivity of this area using two complementary approaches: (1) resting-state connectivity of the aMCC based on fMRI scans obtained in 100 subjects, and (2) functional connectivity in the context of explicit task conditions using meta-analytic connectivity modeling (MACM) over 656 imaging experiment. Both approaches revealed a convergent functional network architecture of the aMCC with prefrontal, premotor and parietal cortices as well as anterior insula, area 44/45, cerebellum and dorsal striatum. To specifically test the role of the aMCC's task-based functional connectivity in cognitive motor control, separate MACM analyses were conducted over cognitive and action related experimental paradigms. Both analyses confirmed the same task-based connectivity pattern of the aMCC. While the cognition domain showed higher convergence of activity in supramodal association areas in prefrontal cortex and anterior insula, action related experiments yielded higher convergence in somatosensory and premotor areas. Secondly, to probe the functional specificity of the aMCC's convergent functional connectivity, it was compared with a neural network of intentional movement initiation. This exemplary comparison confirmed the involvement of the state independent FC network of the aMCC in the intentional generation of movements. In summary, the different experiments of the present study suggest that the aMCC constitute a key region in the network realizing intentional motor control. Hum Brain Mapp 35:2741-2753, 2014. (c) 2013 Wiley Periodicals, Inc.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Hoffstaedter, Felix UNSPECIFIED orcid.org/0000-0001-7163-3110 UNSPECIFIED Grefkes, Christian UNSPECIFIED orcid.org/0000-0002-1656-720X UNSPECIFIED Caspers, Svenja UNSPECIFIED orcid.org/0000-0001-5083-4669 UNSPECIFIED Roski, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Palomero-Gallagher, Nicola UNSPECIFIED orcid.org/0000-0003-4463-8578 UNSPECIFIED Laird, Angie R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fox, Peter T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eickhoff, Simon B. UNSPECIFIED orcid.org/0000-0001-6363-2759 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-437486
DOI:	10.1002/hbm.22363
Journal or Publication Title:	Hum. Brain Mapp.
Volume:	35
Number:	6
Page Range:	S. 2741 - 2754
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-0193
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INFERIOR PARIETAL LOBULE; CINGULATE CORTEX; STRUCTURAL CONNECTIVITY; CYTOARCHITECTONIC AREAS; HUMAN BRAIN; RHESUS-MONKEY; FMRI; ACTIVATION; MOVEMENTS; ANTICORRELATIONS Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43748