Universität zu Köln

Winstel, Volker ORCID: 0000-0002-3248-2572, Xia, Guoqing ORCID: 0000-0003-4492-9156 and Pesthel, Andreas (2014). Pathways and roles of wall teichoic acid glycosylation in Staphylococcus aureus. Int. J. Med. Microbiol., 304 (3-4). S. 215 - 222. JENA: ELSEVIER GMBH, URBAN & FISCHER VERLAG. ISSN 1618-0607

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Abstract

The thick peptidoglycan layers of Gram-positive bacteria are connected to polyanionic glycopolymers called wall teichoic acids (WTA). Pathogens such as Staphylococcus aureus, Listeria monocytogenes, or Enterococcus faecalis produce WTA with diverse, usually strain-specific structure. Extensive studies on S. aureus WTA mutants revealed important functions of WTA in cell division, growth, morphogenesis, resistance to antimicrobials, and interaction with host or phages. While most of the S. aureus WTA-biosynthetic genes have been identified it remained unclear for long how and why S. aureus glycosylates WTA with alpha or beta-linked N-acetylglucosamine (GlcNAc). Only recently the discovery of two WTA glycosyltransferases, TarM and TarS, yielded fundamental insights into the roles of S. aureus WTA glycosylation. Mutants lacking WTA GlcNAc are resistant towards most of the S. aureus phages and, surprisingly, TarS-mediated WTA beta-O-GlcNAc modification is essential for beta-lactam resistance in methicillin-resistant S. aureus. Notably, S. aureus WTA GlcNAc residues are major antigens and activate the complement system contributing to opsonophagocytosis. WTA glycosylation with a variety of sugars and corresponding glycosyltransferases were also identified in other Gram-positive bacteria, which paves the way for detailed investigations on the diverse roles of WTA modification with sugar residues. (C) 2013 Elsevier GmbH. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Winstel, Volker UNSPECIFIED orcid.org/0000-0002-3248-2572 UNSPECIFIED Xia, Guoqing UNSPECIFIED orcid.org/0000-0003-4492-9156 UNSPECIFIED Pesthel, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-438849
DOI:	10.1016/j.ijmm.2013.10.009
Journal or Publication Title:	Int. J. Med. Microbiol.
Volume:	304
Number:	3-4
Page Range:	S. 215 - 222
Date:	2014
Publisher:	ELSEVIER GMBH, URBAN & FISCHER VERLAG
Place of Publication:	JENA
ISSN:	1618-0607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MANNOSE-BINDING LECTIN; COMPLEMENT-MEDIATED OPSONOPHAGOCYTOSIS; BACTERIOPHAGE-RESISTANT MUTANTS; GRAM-POSITIVE BACTERIA; BACILLUS-SUBTILIS 168; CELL-WALL; STREPTOCOCCUS-PNEUMONIAE; LIPOTEICHOIC ACID; KINETIC MECHANISM; CRYSTAL-STRUCTURE Multiple languages Microbiology; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43884