Universität zu Köln

Kuerten, Stefanie, Pommerschein, Giovanna, Barth, Stefanie K., Hohmann, Christopher, Milles, Bianca, Sammer, Fabian W., Duffy, Cathrina E., Wunsch, Marie, Rovituso, Damiano M., Schroeter, Michael, Addicks, Klaus, Kaiser, Claudia C. and Lehmann, Paul V. (2014). Identification of a B cell-dependent subpopulation of multiple sclerosis by measurements of brain-reactive B cells in the blood. Clin. Immunol., 152 (1-2). S. 20 - 25. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1521-7035

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Abstract

B cells are increasingly coming into play in the pathogenesis of multiple sclerosis (MS). Here, we screened peripheral blood mononuclear cells (PBMC) from patients with clinically isolated syndrome (CIS), MS, other non-inflammatory neurological, inflammatory neurological or autoimmune diseases, and healthy donors for their B cell reactivity to CNS antigen using the enzyme-linked immunospot technique (ELISPOT) after 96 h of polyclonal stimulation. Our data show that nine of 15 patients with CIS (60.0%) and 53 of 67 patients with definite MS (79.1%) displayed CNS-reactive B cells, compared to none of the control donors. The presence of CNS-reactive B cells in the blood of the majority of patients with MS or at risk to develop MS along with their absence in control subjects suggests that they might be indicative of a B cell-dependent subpopulation of the disease. (C) 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kuerten, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Pommerschein, Giovanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Barth, Stefanie K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hohmann, Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED Milles, Bianca UNSPECIFIED UNSPECIFIED UNSPECIFIED Sammer, Fabian W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Duffy, Cathrina E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunsch, Marie UNSPECIFIED UNSPECIFIED UNSPECIFIED Rovituso, Damiano M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeter, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Addicks, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaiser, Claudia C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, Paul V. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439323
DOI:	10.1016/j.clim.2014.02.014
Journal or Publication Title:	Clin. Immunol.
Volume:	152
Number:	1-2
Page Range:	S. 20 - 25
Date:	2014
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1521-7035
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIMYELIN ANTIBODIES; CORTICAL PATHOLOGY; HETEROGENEITY; PATHOGENESIS; PROGRESSION Multiple languages Immunology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43932