Universität zu Köln

Harrison, Simon J., Hsu, Andy K., Neeson, Paul ORCID: 0000-0002-2729-5887, Younes, Anas, Sureda, Anna, Engert, Andreas, Prince, H. Miles, Li, Martha, Savage, Paula, Bugarini, Roberto, Williams, Denise, Squier, Margaret and Ritchie, David S. (2014). Early thymus and activation-regulated chemokine (TARC) reduction and response following panobinostat treatment in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant. Leuk. Lymphoma, 55 (5). S. 1053 - 1061. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

In a phase 2 trial of panobinostat in 129 patients with relapsed or refractory Hodgkin lymphoma, exploratory analyses of chemokines and cytokines were prospectively performed in 109 patients to determine their association with clinical outcomes. Patients were categorized into two groups (reductions > median and reductions <= median) based on percentage change from baseline of log(10) transformed measurements. Thymus and activation-regulated chemokine (TARC) was most strongly associated with clinical outcome. Early reduction of TARC was observed in responding patients, with the greatest reduction at cycle 1, day 15 (C1D15). Of 93 patients with C1D15 samples, there were three complete and 25 partial responses. The group with TARC reductions > median at C1D15 had more responders (18 [39%] vs. 10 [21%]), longer progression-free survival (10.6 vs. 4.9 months), shorter time to response and longer overall survival than the group with reductions <= median. This study is registered at www. ClinicalTrials.gov, NCT00742027.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Harrison, Simon J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hsu, Andy K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neeson, Paul UNSPECIFIED orcid.org/0000-0002-2729-5887 UNSPECIFIED Younes, Anas UNSPECIFIED UNSPECIFIED UNSPECIFIED Sureda, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Engert, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Prince, H. Miles UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Martha UNSPECIFIED UNSPECIFIED UNSPECIFIED Savage, Paula UNSPECIFIED UNSPECIFIED UNSPECIFIED Bugarini, Roberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, Denise UNSPECIFIED UNSPECIFIED UNSPECIFIED Squier, Margaret UNSPECIFIED UNSPECIFIED UNSPECIFIED Ritchie, David S. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439381
DOI:	10.3109/10428194.2013.820287
Journal or Publication Title:	Leuk. Lymphoma
Volume:	55
Number:	5
Page Range:	S. 1053 - 1061
Date:	2014
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REED-STERNBERG CELLS; DEACETYLASE INHIBITOR; EXPRESSION; LBH589; GROWTH; LINES; SURVIVAL; CRITERIA Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43938