Zander, Esther, Bonnin, Remy A. ORCID: 0000-0002-2307-3232, Seifert, Harald and Higgins, Paul G. ORCID: 0000-0001-8677-9454 (2014). Characterization of bla(OXA-143) Variants in Acinetobacter baumannii and Acinetobacter pittii. Antimicrob. Agents Chemother., 58 (5). S. 2704 - 2709. WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-6596
Full text not available from this repository.Abstract
The acquired carbapenem- hydrolyzing oxacillinase ( OXA) OXA- 143 has thus far been detected only in Acinetobacter baumannii isolates from Brazil. The aim of this study was to characterize three OXA- 143 variants: OXA- 231 and OXA- 253 from carbapenem-resistant A. baumannii isolates and OXA- 255 in a carbapenem- susceptible Acinetobacter pittii isolate originating from Brazil, Honduras, and the United States, respectively. The 5' rapid amplification of cDNA ends ( RACE) technique identified the same transcription initiation site for all bla(OXA-143-like) genes and revealed differences in the putative promoter regions. However, all cloned OXA- 143 variants conferred carbapenem resistance on A. baumannii ATCC 17978 and OXA- 255 conferred carbapenem resistance on A. pittii SH024, which was correlated with blaOXA- 255 gene expression. This is the first description of OXA- 143- like outside A. baumannii. Detection of OXA- 143- like in the United States and Honduras indicates its dissemination through the American continent.
Item Type: | Journal Article | ||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-439805 | ||||||||||||||||||||
DOI: | 10.1128/AAC.02618-13 | ||||||||||||||||||||
Journal or Publication Title: | Antimicrob. Agents Chemother. | ||||||||||||||||||||
Volume: | 58 | ||||||||||||||||||||
Number: | 5 | ||||||||||||||||||||
Page Range: | S. 2704 - 2709 | ||||||||||||||||||||
Date: | 2014 | ||||||||||||||||||||
Publisher: | AMER SOC MICROBIOLOGY | ||||||||||||||||||||
Place of Publication: | WASHINGTON | ||||||||||||||||||||
ISSN: | 1098-6596 | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/43980 |
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