Universität zu Köln

Zander, Esther, Bonnin, Remy A. ORCID: 0000-0002-2307-3232, Seifert, Harald and Higgins, Paul G. ORCID: 0000-0001-8677-9454 (2014). Characterization of bla(OXA-143) Variants in Acinetobacter baumannii and Acinetobacter pittii. Antimicrob. Agents Chemother., 58 (5). S. 2704 - 2709. WASHINGTON: AMER SOC MICROBIOLOGY. ISSN 1098-6596

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Abstract

The acquired carbapenem- hydrolyzing oxacillinase ( OXA) OXA- 143 has thus far been detected only in Acinetobacter baumannii isolates from Brazil. The aim of this study was to characterize three OXA- 143 variants: OXA- 231 and OXA- 253 from carbapenem-resistant A. baumannii isolates and OXA- 255 in a carbapenem- susceptible Acinetobacter pittii isolate originating from Brazil, Honduras, and the United States, respectively. The 5' rapid amplification of cDNA ends ( RACE) technique identified the same transcription initiation site for all bla(OXA-143-like) genes and revealed differences in the putative promoter regions. However, all cloned OXA- 143 variants conferred carbapenem resistance on A. baumannii ATCC 17978 and OXA- 255 conferred carbapenem resistance on A. pittii SH024, which was correlated with blaOXA- 255 gene expression. This is the first description of OXA- 143- like outside A. baumannii. Detection of OXA- 143- like in the United States and Honduras indicates its dissemination through the American continent.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zander, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Bonnin, Remy A. UNSPECIFIED orcid.org/0000-0002-2307-3232 UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Higgins, Paul G. UNSPECIFIED orcid.org/0000-0001-8677-9454 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-439805
DOI:	10.1128/AAC.02618-13
Journal or Publication Title:	Antimicrob. Agents Chemother.
Volume:	58
Number:	5
Page Range:	S. 2704 - 2709
Date:	2014
Publisher:	AMER SOC MICROBIOLOGY
Place of Publication:	WASHINGTON
ISSN:	1098-6596
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PREVALENT OXA CARBAPENEMASES; MOLECULAR EPIDEMIOLOGY; PCR; HOSPITALS; BRAZIL; GENES; ASSOCIATION; RESISTANCE; EMERGENCE; OXA-143 Multiple languages Microbiology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/43980