Universität zu Köln

Schweer, K. E., Bangard, C., Hekmat, K. and Cornely, O. A. (2014). Chronic pulmonary aspergillosis. Mycoses, 57 (5). S. 257 - 271. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Chronic pulmonary aspergillosis (CPA) is a group of consuming diseases usually presenting with prolonged and relapsing cough, dyspnoea and weight loss. Acute symptoms such as haemoptysis and bronchial or pulmonary haemorrhage may occasionally occur. CPA affects patients with underlying pulmonary conditions, for example, chronic obstructive pulmonary disease or mycobacteriosis or common immunosuppressive conditions such as diabetes. Precise epidemiology is unknown, and while prevalence is considered low the chronic and relapsing nature of the disease challenges the treating physician. Diagnostics largely rely on serologic Aspergillus precipitins and findings on thoracic computed tomography. The latter are manifold comprising cavity formation, pleural involvement and sometimes aspergilloma. Other markers for aspergillosis are less helpful, in part due to the non- or semi-invasive nature of these forms of Aspergillus infection. Various antifungals were shown to be effective in CPA treatment. Azoles are the most frequently applied antifungals in the outpatient setting, but are now compromised by findings of Aspergillus resistance. Long-term prognosis is not fully elucidated and may be driven by the underlying morbidities. Prospective registry-type studies may be suitable to systematically broaden our CPA knowledge base. This article gives an overview of the available literature and proposes a clinical working algorithm for CPA management.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schweer, K. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bangard, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hekmat, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornely, O. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440220
DOI:	10.1111/myc.12152
Journal or Publication Title:	Mycoses
Volume:	57
Number:	5
Page Range:	S. 257 - 271
Date:	2014
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1439-0507
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LATERAL-FLOW DEVICE; CHRONIC NECROTIZING ASPERGILLOSIS; INTERSTUDY REPRODUCIBILITY; PROGNOSTIC-FACTORS; CHRONIC CAVITARY; AZOLE RESISTANCE; GLOBAL BURDEN; HEALTH-STATUS; CYP51A GENE; CASE SERIES Multiple languages Dermatology; Mycology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44022