Universität zu Köln

Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Haase, Ingo and Nestle, Frank O. (2014). Mechanisms regulating skin immunity and inflammation. Nat. Rev. Immunol., 14 (5). S. 289 - 302. LONDON: NATURE PUBLISHING GROUP. ISSN 1474-1741

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Abstract

Immune responses in the skin are important for host defence against pathogenic microorganisms. However, dysregulated immune reactions can cause chronic inflammatory skin diseases. Extensive crosstalk between the different cellular and microbial components of the skin regulates local immune responses to ensure efficient host defence, to maintain and restore homeostasis, and to prevent chronic disease. In this Review, we discuss recent findings that highlight the complex regulatory networks that control skin immunity, and we provide new paradigms for the mechanisms that regulate skin immune responses in host defence and in chronic inflammation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pasparakis, Manolis UNSPECIFIED orcid.org/0000-0002-9870-0966 UNSPECIFIED Haase, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Nestle, Frank O. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440242
DOI:	10.1038/nri3646
Journal or Publication Title:	Nat. Rev. Immunol.
Volume:	14
Number:	5
Page Range:	S. 289 - 302
Date:	2014
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1474-1741
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DELTA-T-CELLS; NF-KAPPA-B; DERMAL DENDRITIC CELLS; INNATE LYMPHOID-CELLS; EPIDERMAL LANGERHANS CELLS; MOUSE MODEL; MAST-CELLS; PLAQUE-FORMATION; RESIDENT MEMORY; PATHOGENIC ROLE Multiple languages Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/44024