Universität zu Köln

Mueller, Nike, Schulte, Dominik M., Hillebrand, Susann, Tuerk, Kathrin, Hampe, Jochen ORCID: 0000-0002-2421-6127, Schafmayer, Clemens, Brosch, Mario ORCID: 0000-0001-8983-6557, von Schoenfels, Witigo, Ahrens, Markus, Zeuner, Rainald, Schroeder, Johann O., Blueher, Matthias, Gutschow, Christian, Freitag-Wolf, Sandra, Stelmach-Mardas, Marta, Saggau, Carina, Schreiber, Stefan and Laudes, Matthias (2014). B Lymphocyte Stimulator (BLyS) Is Expressed in Human Adipocytes In Vivo and Is Related to Obesity but Not to Insulin Resistance. PLoS One, 9 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Inflammation and metabolism have been shown to be evolutionary linked and increasing evidence exists that pro-inflammatory factors are involved in the pathogenesis of obesity and type 2 diabetes. Until now, most data suggest that within adipose tissue these factors are secreted by cells of the innate immune system, e. g. macrophages. In the present study we demonstrate that B lymphocyte stimulator (BLyS) is increased in human obesity. In contrast to several pro-inflammatory factors, we found the source of BLyS in human adipose tissue to be the adipocytes rather than immune cells. In grade 3 obese human subjects, expression of BLyS in vivo in adipose tissue is significantly increased (p<0.001). Furthermore, BLyS serum levels are elevated in grade 3 human obesity (862.5+222.0 pg/ml vs. 543.7+60.7 pg/ml in lean controls, p<0.001) and are positively correlated to the BMI (r = 0.43, p<0.0002). In the present study, bariatric surgery significantly altered serum BLyS concentrations. In contrast, weight loss due to a very-low-calorie-formula-diet (800 kcal/d) had no such effect. To examine metabolic activity of BLyS, in a translational research approach, insulin sensitivity was measured in human subjects in vivo before and after treatment with the human recombinant anti-BLyS antibody belimumab. Since BLyS is known to promote B-cell proliferation and immunoglobulin secretion, the present data suggest that adipocytes of grade 3 obese human subjects are able to activate the adaptive immune system, suggesting that in metabolic inflammation in humans both, innate and adaptive immunity, are of pathophysiological relevance.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Nike UNSPECIFIED UNSPECIFIED UNSPECIFIED Schulte, Dominik M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillebrand, Susann UNSPECIFIED UNSPECIFIED UNSPECIFIED Tuerk, Kathrin UNSPECIFIED UNSPECIFIED UNSPECIFIED Hampe, Jochen UNSPECIFIED orcid.org/0000-0002-2421-6127 UNSPECIFIED Schafmayer, Clemens UNSPECIFIED UNSPECIFIED UNSPECIFIED Brosch, Mario UNSPECIFIED orcid.org/0000-0001-8983-6557 UNSPECIFIED von Schoenfels, Witigo UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahrens, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeuner, Rainald UNSPECIFIED UNSPECIFIED UNSPECIFIED Schroeder, Johann O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Blueher, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Gutschow, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Freitag-Wolf, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Stelmach-Mardas, Marta UNSPECIFIED UNSPECIFIED UNSPECIFIED Saggau, Carina UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreiber, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Laudes, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-440724
DOI:	10.1371/journal.pone.0094282
Journal or Publication Title:	PLoS One
Volume:	9
Number:	4
Date:	2014
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NECROSIS-FACTOR FAMILY; ADIPOSE-TISSUE; METABOLIC SYNDROME; CELLS; BAFF; ASSOCIATION; MECHANISMS; OVERWEIGHT; IMPACT; WNT-5A Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/44072